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    PFK26 6-phosphofructo-2-kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PFK26
    Official Full Name
    6-phosphofructo-2-kinase
    Primary source
    SGD:S000001369
    Locus tag
    YIL107C
    See related
    AllianceGenome:SGD:S000001369; FungiDB:YIL107C; VEuPathDB:YIL107C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 6-phosphofructo-2-kinase activity. Involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PFK26 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (163278..165761, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene COPII subunit SEC24 Neighboring gene putative metalloendopeptidase Neighboring gene Mob1p Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast 6-phosphofructo-2-kinase: sequence and mutant. Kretschmer M, et al. Biochemistry, 1991 Nov 5. PMID 1657152
    2. Lysine 3 acetylation regulates the phosphorylation of yeast 6-phosphofructo-2-kinase under hypo-osmotic stress. Dihazi H, et al. Biol Chem, 2005 Sep. PMID 16164414
    3. Ser644 is important for catalytic activity but is not involved in cAMP-dependent phosphorylation of yeast 6-phosphofructo-2-kinase. Kessler R, et al. FEBS Lett, 1996 Oct 21. PMID 8898101
    4. High osmolarity glycerol (HOG) pathway-induced phosphorylation and activation of 6-phosphofructo-2-kinase are essential for glycerol accumulation and yeast cell proliferation under hyperosmotic stress. Dihazi H, et al. J Biol Chem, 2004 Jun 4. PMID 15037628
    5. Mutant studies of phosphofructo-2-kinases do not reveal an essential role of fructose-2,6-bisphosphate in the regulation of carbon fluxes in yeast cells. Müller S, et al. Microbiology (Reading), 1997 Sep. PMID 9308187

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 6-phosphofructo-2-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fructose 2,6-bisphosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fructose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    6-phosphofructo-2-kinase
    NP_012159.1
    • 6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      163278..165761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179455.1 → NP_012159.1  TPA: 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012159.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVI0, P40433
      UniProtKB/TrEMBL
      A6ZVH0, B3LTV4, C7GKN3, C8ZAD8, N1P1Y7
      Conserved Domains (2) summary
      COG0406
      Location:397 → 608
      PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
      pfam01591
      Location:171 → 396
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40433.1

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