DST1 transcription elongation factor DST1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DST1
Official Full Name: transcription elongation factor DST1
Primary source: SGD:S000003011
Locus tag: YGL043W
See related: AllianceGenome:SGD:S000003011; FungiDB:YGL043W; VEuPathDB:YGL043W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PPR2
Summary: Enables RNA polymerase II complex recruiting activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in DNA-templated transcription and regulation of RNA metabolic process. Located in nucleus. Orthologous to several human genes including TCEA1 (transcription elongation factor A1); TCEA2 (transcription elongation factor A2); and TCEA3 (transcription elongation factor A3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DST1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (417483..418412)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs.
Title: Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs.
Dst1, a homolog of mammalian transcription elongation factor TFIIS, interferes with NER-dependent repair of AP lesions while suppressing homologous recombination pathway.
Title: Def1 and Dst1 play distinct roles in repair of AP lesions in highly transcribed genomic regions.
TFIIF mainly prevents Pol II from pause entering, whereas TFIIS assists with pause recovery, and quantitatively described these effects on the kinetics of transcription elongation by Pol II.
Title: Transcription factors IIS and IIF enhance transcription efficiency by differentially modifying RNA polymerase pausing dynamics.
Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability is provided.
Title: Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability.
Data show that two components of the RNA polymerase II machinery, Med13 (Srb9) and Spt8, are two-hybrid partners of the conserved TFIIS N-terminal domain.
Title: Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II complex recruiting activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA 3'-end processing	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription antitermination	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase III	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription elongation factor DST1

NP_011472.1

General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

417483..418412

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180908.1 → NP_011472.1 TPA: transcription elongation factor DST1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011472.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VU96, P07273, P24535

UniProtKB/TrEMBL

A6ZUV3, B3LIQ3, C7GS22, C8Z8K0, G2WE52, N1P9R9

Conserved Domains (1) summary

TIGR01385
Location:3 → 309

TFSII; transcription elongation factor S-II