U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MRM2 21S rRNA (uridine2791-2'-O) methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852741, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MRM2
    Official Full Name
    21S rRNA (uridine2791-2'-O) methyltransferase
    Primary source
    SGD:S000003104
    Locus tag
    YGL136C
    See related
    AllianceGenome:SGD:S000003104; FungiDB:YGL136C; VEuPathDB:YGL136C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA (uridine-2'-O-)-methyltransferase activity. Involved in rRNA methylation. Located in mitochondrion. Used to study MELAS syndrome. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MRM2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (252897..253859, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene coatomer subunit beta' Neighboring gene ribosomal 60S subunit protein L1B Neighboring gene Pcl10p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. Pintard L, et al. EMBO J, 2002 Mar 1. PMID 11867542, Free PMC Article
    2. Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome. Garone C, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973171, Free PMC Article
    3. Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. Pintard L, et al. EMBO J, 2002 Apr 2. PMID 11927565, Free PMC Article
    4. Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Bonnerot C, et al. Mol Cell, 2003 Nov. PMID 14636587
    5. The yeast GTPase Mtg2p is required for mitochondrial translation and partially suppresses an rRNA methyltransferase mutant, mrm2. Datta K, et al. Mol Biol Cell, 2005 Feb. PMID 15591131, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (uridine-2'-O-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (uridine-2'-O-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    21S rRNA (uridine2791-2'-O) methyltransferase
    NP_011379.1
    • Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      252897..253859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181001.1 → NP_011379.1  TPA: 21S rRNA (uridine2791-2'-O) methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011379.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU13, P53123
      UniProtKB/TrEMBL
      A6ZU47, B3LHJ4, C7GPR6, C8Z8B4, G2WDW7, N1P3D6
      Conserved Domains (1) summary
      COG0293
      Location:25 → 310
      RlmE; 23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53123.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools