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    BOL2 Bol2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BOL2
    Official Full Name
    Bol2p
    Primary source
    SGD:S000003188
    Locus tag
    YGL220W
    See related
    AllianceGenome:SGD:S000003188; FungiDB:YGL220W; VEuPathDB:YGL220W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM15; FRA2
    Summary
    Enables iron-sulfur cluster binding activity. Involved in cellular response to iron ion and negative regulation of transcription by RNA polymerase II. Located in cytosol. Orthologous to human BOLA2 (bolA family member 2) and BOLA2B (bolA family member 2B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BOL2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (82374..82736)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Edc1p Neighboring gene uncharacterized protein Neighboring gene ERMES complex subunit MDM34 Neighboring gene tubulin-dependent ATPase KIP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Production of ethylene glycol or glycolic acid from D-xylose in Saccharomyces cerevisiae. Salusjärvi L, et al. Appl Microbiol Biotechnol, 2017 Nov. PMID 29038973
    2. Monothiol glutaredoxins and A-type proteins: partners in Fe-S cluster trafficking. Mapolelo DT, et al. Dalton Trans, 2013 Mar 7. PMID 23292141, Free PMC Article
    3. Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Bishop AL, et al. Mol Microbiol, 2007 Jan. PMID 17176259
    4. Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast. Li H, et al. J Biol Chem, 2011 Jan 7. PMID 20978135, Free PMC Article
    5. The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2. Li H, et al. J Biol Inorg Chem, 2019 Sep. PMID 31493153, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2
      Title: The conserved CDC motif in the yeast iron regulator Aft2 mediates iron-sulfur cluster exchange and protein-protein interactions with Grx3 and Bol2.
    2. Study revealed that Fra2 could form a noncovalent heterodimer with Grx3 via an interface between the helix-turn-helix motif of Fra2 and the C-terminal segment of Grx3(Grx).
      Title: Structural and Biochemical Insights into the Multiple Functions of Yeast Grx3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation by iron-sulfur cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bol2p
    NP_011295.1
    • Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      82374..82736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181085.1 → NP_011295.1  TPA: Bol2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011295.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVB5, P53082
      UniProtKB/TrEMBL
      B3LHR2, C7GWY0, C8Z835, G2WDP1, N1P2I9
      Conserved Domains (1) summary
      COG0271
      Location:23 → 116
      BolA; Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53082.1

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