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    CDC26 anaphase promoting complex subunit CDC26 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC26
    Official Full Name
    anaphase promoting complex subunit CDC26
    Primary source
    SGD:S000001932
    Locus tag
    YFR036W
    See related
    AllianceGenome:SGD:S000001932; FungiDB:YFR036W; VEuPathDB:YFR036W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HIT3; SCD26
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex-dependent catabolic process; chromatin organization; and protein ubiquitination. Located in cytosol and nucleus. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC26 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (226963..227337)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA-Lys Neighboring gene Rsc8p Neighboring gene putative ATPase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The CDC26 gene of Saccharomyces cerevisiae is required for cell growth only at high temperature. Araki H, et al. Mol Gen Genet, 1992 Jan. PMID 1736102
    2. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Wang J, et al. Nat Struct Mol Biol, 2009 Sep. PMID 19668213, Free PMC Article
    3. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Zachariae W, et al. Science, 1996 Nov 15. PMID 8895471
    4. The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Harkness TA, et al. Genetics, 2002 Oct. PMID 12399376, Free PMC Article
    5. A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis. Hwang LH, et al. Mol Biol Cell, 1997 Oct. PMID 9348530, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex subunit CDC26
    NP_116694.1
    • Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      226963..227337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180001.1 → NP_116694.1  TPA: anaphase promoting complex subunit CDC26 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116694.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTR9, P14724
      UniProtKB/TrEMBL
      A7A276, B3LUP7, C7GYE0, C8Z7X2, G2WDH7, N1P4R4
      Conserved Domains (1) summary
      pfam10471
      Location:1 → 59
      ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14724.2

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