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    HEM14 oxygen-dependent protoporphyrinogen oxidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HEM14
    Official Full Name
    oxygen-dependent protoporphyrinogen oxidase
    Primary source
    SGD:S000000816
    Locus tag
    YER014W
    See related
    AllianceGenome:SGD:S000000816; FungiDB:YER014W; VEuPathDB:YER014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process. Located in mitochondrion. Is active in mitochondrial inner membrane. Used to study variegate porphyria. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HEM14 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (182600..184219)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 4 Neighboring gene DEAH-box ATP-dependent RNA helicase PRP22 Neighboring gene Bud25p Neighboring gene medium-chain fatty acid-CoA ligase FAA2 Neighboring gene microtubule-binding protein BIM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX. Protoporphyrinogen oxidase activity in mitochondrial extracts of Saccharomyces cerevisiae. Poulson R, et al. J Biol Chem, 1975 Feb 25. PMID 234450
    2. A new assay for protoporphyrinogen oxidase - evidence for a total deficiency in that activity in a heme-less mutant of Saccharomyces cerevisiae. Camadro JM, et al. Biochem Biophys Res Commun, 1982 Jun 15. PMID 7052077
    3. Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase. Glerum DM, et al. Yeast, 1996 Nov. PMID 8948097
    4. Photoaffinity labeling of protoporphyrinogen oxidase, the molecular target of diphenylether-type herbicides. Camadro JM, et al. Eur J Biochem, 1995 May 1. PMID 7758461
    5. Purification and properties of protoporphyrinogen oxidase from the yeast Saccharomyces cerevisiae. Mitochondrial location and evidence for a precursor form of the protein. Camadro JM, et al. J Biol Chem, 1994 Dec 23. PMID 7798202

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables menaquinone-dependent protoporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen-dependent protoporphyrinogen oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen-dependent protoporphyrinogen oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxygen-dependent protoporphyrinogen oxidase
    NP_010930.1
    • Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      182600..184219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178905.1 → NP_010930.1  TPA: oxygen-dependent protoporphyrinogen oxidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLR1, P40012
      UniProtKB/TrEMBL
      A6ZQW1, B3LS26, B5VHE5, C8Z714
      Conserved Domains (1) summary
      TIGR00562
      Location:24 → 539
      proto_IX_ox; protoporphyrinogen oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40012.1

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