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    CHL4 Chl4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CHL4
    Official Full Name
    Chl4p
    Primary source
    SGD:S000002662
    Locus tag
    YDR254W
    See related
    AllianceGenome:SGD:S000002662; FungiDB:YDR254W; VEuPathDB:YDR254W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CTF17; MCM17
    Summary
    Enables structural molecule activity. Involved in several processes, including chromosome organization; mitotic spindle assembly checkpoint signaling; and protein localization to chromosome, centromeric region. Part of outer kinetochore. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CHL4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (965113..966489)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT core subunit BTT1 Neighboring gene Met32p Neighboring gene ubiquitin-protein ligase RMD5 Neighboring gene catalase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast. Kouprina N, et al. Genetics, 1993 Oct. PMID 8243998, Free PMC Article
    2. [Stable maintenance of dicentric mini-chromosomes in CHL4 mutants in yeast]. Kuprina NIu, et al. Mol Biol (Mosk), 1993 May-Jun. PMID 8316241
    3. Budding yeast kinetochore proteins, Chl4 and Ctf19, are required to maintain SPB-centromere proximity during G1 and late anaphase. Sau S, et al. PLoS One, 2014. PMID 25003500, Free PMC Article
    4. Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly. Guo Q, et al. Acta Crystallogr D Biol Crystallogr, 2013 Dec. PMID 24311582
    5. The mcm17 mutation of yeast shows a size-dependent segregational defect of a mini-chromosome. Roy N, et al. Curr Genet, 1997 Sep. PMID 9339342

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural molecule activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chl4p
    NP_010540.3
    • Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      965113..966489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180562.3 → NP_010540.3  TPA: Chl4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010540.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSN4, P38907
      UniProtKB/TrEMBL
      B3LG36, B5VGD8, C7GTI9, G2WAZ7, N1PAG4
      Conserved Domains (1) summary
      pfam05238
      Location:15 → 445
      CENP-N; Kinetochore protein CHL4 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38907.1

    Gene LinkOut

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