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    QCR7 ubiquinol--cytochrome-c reductase subunit 7 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    QCR7
    Official Full Name
    ubiquinol--cytochrome-c reductase subunit 7
    Primary source
    SGD:S000002937
    Locus tag
    YDR529C
    See related
    AllianceGenome:SGD:S000002937; FungiDB:YDR529C; VEuPathDB:YDR529C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COR4; CRO1; UCR7
    Summary
    Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in inherited metabolic disorder and mitochondrial complex III deficiency nuclear type 3. Orthologous to human UQCRB (ubiquinol-cytochrome c reductase binding protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See QCR7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1496165..1496548, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Hlr1p Neighboring gene bifunctional AP-4-A phosphorylase/ADP sulfurylase Neighboring gene pantothenate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The functional role of conserved acidic residues of the Qcr7 protein of the cytochrome bc(1) complex in Saccharomyces cerevisiae. Lee SY, et al. Arch Biochem Biophys, 2001 Sep 15. PMID 11556807
    2. Inactivation of the gene encoding the 14-kDa subunit VII of yeast ubiquinol. Cytochrome c oxidoreductase and analysis of the resulting mutant. Schoppink PJ, et al. Eur J Biochem, 1989 May 1. PMID 2540976
    3. Subunit VII, the ubiquinone-binding protein, of the cytochrome b-c1 complex of yeast mitochondria is involved in electron transport at center o and faces the matrix side of the membrane. Japa S, et al. J Biol Chem, 1987 Apr 25. PMID 3032932
    4. The N terminus of the Qcr7 protein of the cytochrome bc1 complex is not essential for import into mitochondria in Saccharomyces cerevisiae but is essential for assembly of the complex. Malaney S, et al. J Biol Chem, 1997 Jul 11. PMID 9211895
    5. The C-terminus of the 14-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae is involved in the assembly of a functional enzyme. Hemrika W, et al. Eur J Biochem, 1994 Mar 1. PMID 8125116

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquinol-cytochrome-c reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase subunit 7
    NP_010818.1
    • Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1496165..1496548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180837.1 → NP_010818.1  TPA: ubiquinol--cytochrome-c reductase subunit 7 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTF0, P00128
      UniProtKB/TrEMBL
      A6ZZB6, B3LFE2, C7GKW0, C8Z689, G2WBQ6, N1P5Y3
      Conserved Domains (1) summary
      pfam02271
      Location:19 → 118
      UCR_14kD; Ubiquinol-cytochrome C reductase complex 14kD subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00128.2

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