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    TFC6 transcription factor TFIIIC subunit TFC6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851964, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TFC6
    Official Full Name
    transcription factor TFIIIC subunit TFC6
    Primary source
    SGD:S000002770
    Locus tag
    YDR362C
    See related
    AllianceGenome:SGD:S000002770; FungiDB:YDR362C; VEuPathDB:YDR362C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase III type 1 promoter sequence-specific DNA binding activity and RNA polymerase III type 2 promoter sequence-specific DNA binding activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TFC6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1196679..1198697, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Eaf1p Neighboring gene protein-transporting protein BCP1 Neighboring gene Esc2p Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae. Wang Q, et al. BMC Biol, 2014 Oct 28. PMID 25348158, Free PMC Article
    2. Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly. Mylona A, et al. Mol Cell, 2006 Oct 20. PMID 17052456
    3. Autoregulation of an RNA polymerase II promoter by the RNA polymerase III transcription factor III C (TF(III)C) complex. Kleinschmidt RA, et al. Proc Natl Acad Sci U S A, 2011 May 17. PMID 21536876, Free PMC Article
    4. Expression, proteolytic analysis, reconstitution, and crystallization of the tau60/tau91 subcomplex of yeast TFIIIC. Mylona A, et al. Protein Expr Purif, 2006 Feb. PMID 16115780
    5. Tau91, an essential subunit of yeast transcription factor IIIC, cooperates with tau138 in DNA binding. Arrebola R, et al. Mol Cell Biol, 1998 Jan. PMID 9418847, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III general transcription initiation factor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5S class rRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor TFIIIC subunit TFC6
    NP_010649.1
    • Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1196679..1198697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180670.1 → NP_010649.1  TPA: transcription factor TFIIIC subunit TFC6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSZ0, Q06339
      UniProtKB/TrEMBL
      A6ZYW0, B3LFU1, N1P5C8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06339.1

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