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    FIN1 Fin1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851708, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FIN1
    Official Full Name
    Fin1p
    Primary source
    SGD:S000002537
    Locus tag
    YDR130C
    See related
    AllianceGenome:SGD:S000002537; FungiDB:YDR130C; VEuPathDB:YDR130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule binding activity. A structural constituent of cytoskeleton. Involved in several processes, including cytoskeleton organization; deactivation of mitotic spindle assembly checkpoint; and protein localization to kinetochore. Located in cytoskeleton; kinetochore; and nucleus. Part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FIN1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (715747..716622, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Mtc5p Neighboring gene fimbrin Neighboring gene uncharacterized protein Neighboring gene Mrx16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies. van Hemert MJ, et al. Proc Natl Acad Sci U S A, 2002 Apr 16. PMID 11929974, Free PMC Article
    2. The role of self-association in Fin1 function on the mitotic spindle. Woodbury EL, et al. J Biol Chem, 2007 Nov 2. PMID 17804403
    3. A general strategy for studying multisite protein phosphorylation using label-free selected reaction monitoring mass spectrometry. Eissler CL, et al. Anal Biochem, 2011 Nov 15. PMID 21810403, Free PMC Article
    4. Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast. van Hemert MJ, et al. J Biol Chem, 2003 Apr 25. PMID 12551942
    5. Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase. Bokros M, et al. PLoS Genet, 2021 May. PMID 34033659, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
      Title: Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.
    2. Our results suggest the stoichiometry of outer kinetochore submodules is strongly influenced by factors at the kinetochore-microtubule interface such as Fin1 and Dam1, and phosphorylation by cyclin-dependent kinase.
      Title: The stoichiometry of the outer kinetochore is modulated by microtubule-proximal regulatory factors.
    3. used quantitative proteomics to identify the Fin1 protein as a PP1 regulatory subunit
      Title: Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.
    4. Findings suggest that the N-terminal region of Fin1 is sufficient for its regulated function as a spindle-stabilizing factor and that this function involves association with the spindle pole body.
      Title: The role of self-association in Fin1 function on the mitotic spindle.
    5. we identify the budding-yeast protein Fin1 as a spindle-stabilizing protein whose activity is strictly limited to anaphase by changes in its phosphorylation state and rate of degradation.
      Title: Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deactivation of mitotic spindle assembly checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in deactivation of mitotic spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intermediate filament cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase type 1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fin1p
    NP_010415.1
    • Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      715747..716622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180438.1 → NP_010415.1  TPA: Fin1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010415.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSB6, Q03898
      UniProtKB/TrEMBL
      B5VG28, C7GIN8, C8Z546
      Conserved Domains (1) summary
      pfam17300
      Location:15 → 283
      FIN1; Filament protein FIN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03898.1

    Gene LinkOut

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