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    GIS1 histone demethylase GIS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GIS1
    Official Full Name
    histone demethylase GIS1
    Primary source
    SGD:S000002503
    Locus tag
    YDR096W
    See related
    AllianceGenome:SGD:S000002503; FungiDB:YDR096W; VEuPathDB:YDR096W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3K36 demethylase activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of phospholipid biosynthetic process. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4A (lysine demethylase 4A); KDM4B (lysine demethylase 4B); and KDM4C (lysine demethylase 4C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GIS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (637139..639823)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene E2 ubiquitin-conjugating protein UBC13 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF2 Neighboring gene mismatch repair ATPase MSH6 Neighboring gene monothiol glutaredoxin GRX3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transcription activity of Gis1 is negatively modulated by proteasome-mediated limited proteolysis. Zhang N, et al. J Biol Chem, 2010 Feb 26. PMID 20022953, Free PMC Article
    2. Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family. Lal S, et al. Nucleic Acids Res, 2018 Jan 9. PMID 29126261, Free PMC Article
    3. The JmjC domain of Gis1 is dispensable for transcriptional activation. Yu Y, et al. FEMS Yeast Res, 2010 Nov. PMID 20868382, Free PMC Article
    4. JmjN interacts with JmjC to ensure selective proteolysis of Gis1 by the proteasome. Quan Z, et al. Microbiology (Reading), 2011 Sep. PMID 21680636
    5. The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae. Bonzanni N, et al. Bioinformatics, 2011 Jul 1. PMID 21685082, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that histone demethylase GIS1 (Gis1)represents a class of multi-functional heme sensing and signaling proteins.
      Title: Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family.
    2. In vivo experiments showed that, for the Gis1 transcription factor at least, proteasome-mediated control is crucial for a rapid return to growth after nutrient starvation.
      Title: The role of proteosome-mediated proteolysis in modulating potentially harmful transcription factor activity in Saccharomyces cerevisiae.
    3. The data demonstrate that the JmjC domain is dispensable for transcriptional activation by Gis1 during nutrient stress and sporulation.
      Title: The JmjC domain of Gis1 is dispensable for transcriptional activation.
    4. Gis1 is responsible for upregulation of genes during transition from growth to stationary phase.
      Title: Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K36 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone modifying activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone demethylase GIS1
    NP_010381.1
    • Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      637139..639823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180404.1 → NP_010381.1  TPA: histone demethylase GIS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010381.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS81, Q03833
      UniProtKB/TrEMBL
      C7GVP2
      Conserved Domains (5) summary
      smart00545
      Location:11 → 52
      JmjN; Small domain found in the jumonji family of transcription factors
      pfam02373
      Location:191 → 307
      JmjC; JmjC domain, hydroxylase
      sd00017
      Location:830 → 851
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:842 → 868
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:828 → 851
      zf-C2H2_4; C2H2-type zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03833.1

    Gene LinkOut

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