STE7 mitogen-activated protein kinase kinase STE7 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: STE7
Official Full Name: mitogen-activated protein kinase kinase STE7
Primary source: SGD:S000002318
Locus tag: YDL159W
See related: AllianceGenome:SGD:S000002318; FungiDB:YDL159W; VEuPathDB:YDL159W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables MAP kinase kinase activity. Involved in several processes, including MAPK cascade; invasive growth in response to glucose limitation; and pseudohyphal growth. Located in cytoplasm and mating projection tip. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; cardiofaciocutaneous syndrome 4; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1) and MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See STE7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (172481..174028)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ste7 ubiquitination determines mitogen-activated protein kinase specificity
Title: Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity.
Data show that that two alternative MAPKKs, Pbs2 and Mkk2, can be forced to functionally replace the mating MAPKK Ste7, but only if the proper set of recruitment interactions are grafted onto their catalytic domains.
Title: Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.
Data support the model that Fus3 activation in vivo requires binding to both Ste7 and the scaffold-Ste5, but that Kss1 activation is independent of Ste5.
Title: Persistent activation by constitutive Ste7 promotes Kss1-mediated invasive growth but fails to support Fus3-dependent mating in yeast.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in cell integrity MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in invasive growth in response to glucose limitation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone response MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in pheromone response MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pheromone response MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pheromone response MAPK cascade	IPI Inferred from Physical Interaction more info	PubMed
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in pseudohyphal growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in response to pheromone triggering conjugation with cellular fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction involved in filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase STE7

NP_010122.1

EC 2.7.12.2

Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

172481..174028

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180219.1 → NP_010122.1 TPA: mitogen-activated protein kinase kinase STE7 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010122.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRJ2, P06784

UniProtKB/TrEMBL

A6ZXH1, B3LH45, G2WC05, N1P953

Conserved Domains (1) summary

cd06620
Location:185 → 482

PKc_Byr1_like; Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases