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    AVT6 aspartate/glutamate transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AVT6
    Official Full Name
    aspartate/glutamate transporter
    Primary source
    SGD:S000000921
    Locus tag
    YER119C
    See related
    AllianceGenome:SGD:S000000921; FungiDB:YER119C; VEuPathDB:YER119C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Involved in amino acid transmembrane export from vacuole. Located in fungal-type vacuole membrane. Orthologous to human SLC38A5 (solute carrier family 38 member 5) and SLC38A7 (solute carrier family 38 member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AVT6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (399496..400842, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L23B Neighboring gene osmosensor SHO1 Neighboring gene phosphatidylinositol-binding protein SCS2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for Avt6 as a vacuolar exporter of acidic amino acids in Saccharomyces cerevisiae cells. Chahomchuen T, et al. J Gen Appl Microbiol, 2009 Dec. PMID 20118605
    2. The vacuolar amino acid transport system is a novel, direct target of GATA transcription factors. Sato A, et al. Biosci Biotechnol Biochem, 2021 Feb 24. PMID 33624780
    3. Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae. Nishida I, et al. J Gen Appl Microbiol, 2016 Jul 14. PMID 27246536
    4. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. Russnak R, et al. J Biol Chem, 2001 Jun 29. PMID 11274162
    5. Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae. Lawrence MBD, et al. Genetics, 2017 Sep. PMID 28739661, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-aspartate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-histidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-tyrosine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-aspartate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-serine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartate/glutamate transporter
    NP_011044.1
    • Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      399496..400842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179009.1 → NP_011044.1  TPA: aspartate/glutamate transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM25, P40074
      UniProtKB/TrEMBL
      A6ZR74, G2WD05, N1P3J6
      Conserved Domains (1) summary
      pfam01490
      Location:1 → 439
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40074.1

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