PHO5 acid phosphatase PHO5 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHO5
Official Full Name: acid phosphatase PHO5
Primary source: SGD:S000000297
Locus tag: YBR093C
See related: AllianceGenome:SGD:S000000297; FungiDB:YBR093C; VEuPathDB:YBR093C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables acid phosphatase activity; nucleoside triphosphate diphosphatase activity; and ribonucleoside triphosphate phosphatase activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in fungal-type cell wall. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma and pontocerebellar hypoplasia type 16. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PHO5 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (429548..430951, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A review of the PHO5 promoter as a paradigm for gene regulation through chromatin remodeling.
Title: The yeast PHO5 promoter: from single locus to systems biology of a paradigm for gene regulation through chromatin.
three histone methylation mutants exhibited more severe growth defects and slower activation of GAL1, SSA3 and PHO5 than those of wild type
Title: [Effects of histone H3 K4L and K36L mutations on the cell growth and the transcription of GAL1, SSA3 and PHO5 in Saccharomyces cerevisiae].
The results show that remodels the structure of chromatin (RSC) is crucially involved in PHO5 promoter opening.
Title: The RSC chromatin remodeling complex has a crucial role in the complete remodeler set for yeast PHO5 promoter opening.
we provide evidence that topoisomerases are required to maintain the PHO5 promoter in a superhelical state, which is competent for proper activation.
Title: DNA Topoisomerases maintain promoters in a state competent for transcriptional activation in Saccharomyces cerevisiae.
data suggest that Set1-mediated H3K4me suppresses nucleosome remodeling at the PHO5 promoter so as to reduce basal transcription of PHO5 under repressive conditions
Title: Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter.
auxiliary role for DNA binding competition between Pho4 and histones in PHO5 promoter chromatin remodeling
Title: In vitro reconstitution of PHO5 promoter chromatin remodeling points to a role for activator-nucleosome competition in vivo.
The Mcm1-Fkh2 complex, first shown to transactivate genes within the CLB2 cluster that drive G(2)/M progression, also associated directly at the PHO5 promoter in a cell cycle-dependent manner.
Title: Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.
Nap1 regulates transcription of PHO5.
Title: Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.
analysis of complete independence of promoter chromatin opening from downstream PHO5 transcription processes
Title: Redundancy of chromatin remodeling pathways for the induction of the yeast PHO5 promoter in vivo.
Chromatin diassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
Title: Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables nucleoside triphosphate diphosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside triphosphate phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ribonucleoside triphosphate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate-containing compound metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell size	HMP more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in fungal-type cell wall	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acid phosphatase PHO5

NP_009651.3

EC 3.1.3.2

Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

429548..430951 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178441.3 → NP_009651.3 TPA: acid phosphatase PHO5 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009651.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ94, P00635

UniProtKB/TrEMBL

A6ZL40, B3LN58, D3UEI8

Conserved Domains (1) summary

pfam00328
Location:65 → 399

His_Phos_2; Histidine phosphatase superfamily (branch 2)