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    KTR6 putative mannosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856054, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KTR6
    Official Full Name
    putative mannosyltransferase
    Primary source
    SGD:S000005974
    Locus tag
    YPL053C
    See related
    AllianceGenome:SGD:S000005974; FungiDB:YPL053C; VEuPathDB:YPL053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MNN6
    Summary
    Enables mannosylphosphate transferase activity. Involved in fungal-type cell wall organization and protein N-linked glycosylation. Acts upstream of or within endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KTR6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (457118..458458, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Lge1p Neighboring gene Lee1p Neighboring gene Oaz1p Neighboring gene Arf family GTPase ARL3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MNN6, a member of the KRE2/MNT1 family, is the gene for mannosylphosphate transfer in Saccharomyces cerevisiae. Wang XH, et al. J Biol Chem, 1997 Jul 18. PMID 9218445
    2. A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions. Mora-Montes HM, et al. J Biol Chem, 2010 Apr 16. PMID 20164191, Free PMC Article
    3. Biosynthesis of yeast mannan. Properties of a mannosylphosphate transferase in Saccharomyces cerevisiae. Karson EM, et al. J Biol Chem, 1978 Sep 25. PMID 355255
    4. Mannosylphosphate transfer to cell wall mannan is regulated by the transcriptional level of the MNN4 gene in Saccharomyces cerevisiae. Odani T, et al. FEBS Lett, 1997 Dec 29. PMID 9459307
    5. Both Svp26 and Mnn6 are required for the efficient ER exit of Mnn4 in Saccharomyces cerevisiae. Noda Y, et al. J Gen Appl Microbiol, 2019 Dec 19. PMID 30842360

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ybl006c (Rsc14) controls expression of MNN6, MNN4 and MNN1
      Title: Rsc14-controlled expression of MNN6, MNN4 and MNN1 regulates mannosylphosphorylation of Saccharomyces cerevisiae cell wall mannoproteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosylphosphate transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mannosyltransferase
    NP_015272.1
    • Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; facilitates the exit of Mnn4p from the ER via COPII-coated vesicles; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      457118..458458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183867.1 → NP_015272.1  TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W1, P54070
      UniProtKB/TrEMBL
      A6ZWJ5, B3LL14, C7GU02, C8ZIX7, G2WPC5
      Conserved Domains (1) summary
      COG5020
      Location:7 → 443
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54070.1

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