U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TUF1 translation elongation factor Tu [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854359, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TUF1
    Official Full Name
    translation elongation factor Tu
    Primary source
    SGD:S000005713
    Locus tag
    YOR187W
    See related
    AllianceGenome:SGD:S000005713; FungiDB:YOR187W; VEuPathDB:YOR187W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity and translation elongation factor activity. Involved in mitochondrial translational elongation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TUF1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (684030..685343)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ran GTPase GSP2 Neighboring gene uncharacterized protein Neighboring gene Msb1p Neighboring gene Ies4p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Purification and characterization of Saccharomyces cerevisiae mitochondrial elongation factor Tu. Rosenthal LP, et al. J Biol Chem, 1987 Aug 15. PMID 3301847
    2. The yeast counterparts of human 'MELAS' mutations cause mitochondrial dysfunction that can be rescued by overexpression of the mitochondrial translation factor EF-Tu. Feuermann M, et al. EMBO Rep, 2003 Jan. PMID 12524521, Free PMC Article
    3. Analyzing the suppression of respiratory defects in the yeast model of human mitochondrial tRNA diseases. Montanari A, et al. Gene, 2013 Sep 15. PMID 23727608
    4. Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae. Myers AM, et al. EMBO J, 1985 Aug. PMID 3905388, Free PMC Article
    5. Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae. Nagata S, et al. Proc Natl Acad Sci U S A, 1983 Oct. PMID 6353412, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of the relationships between EF-Ts and EF-Tu from both yeasts and humans through functional complementation and coexpression experiments
      Title: Mitochondrial translation: elongation factor tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    translation elongation factor Tu
    NP_014830.1
    • Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      684030..685343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183606.1 → NP_014830.1  TPA: translation elongation factor Tu [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2P3, P02992
      UniProtKB/TrEMBL
      A6ZP32, B3LJL7, B5VS71, C7GLQ7, C8ZGU7, G2WN60, N1NX38
      Conserved Domains (1) summary
      PRK00049
      Location:40 → 437
      PRK00049; elongation factor Tu; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02992.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools