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    MFA2 mating pheromone a [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MFA2
    Official Full Name
    mating pheromone a
    Primary source
    SGD:S000005089
    Locus tag
    YNL145W
    See related
    AllianceGenome:SGD:S000005089; FungiDB:YNL145W; VEuPathDB:YNL145W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MFA2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (352414..352530)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene: mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences. Teng Y, et al. J Mol Biol, 1997 Mar 28. PMID 9096229
    2. Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Muhlrad D, et al. Genes Dev, 1992 Nov. PMID 1427074
    3. Histone acetylation, chromatin remodelling and nucleotide excision repair: hint from the study on MFA2 in Saccharomyces cerevisiae. Yu Y, et al. Cell Cycle, 2005 Aug. PMID 16082210
    4. Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Yuan YL, et al. Mol Cell Biol, 1991 Dec. PMID 1944269, Free PMC Article
    5. The mapping of nucleosomes and regulatory protein binding sites at the Saccharomyces cerevisiae MFA2 gene: a high resolution approach. Teng Y, et al. Nucleic Acids Res, 2001 Jul 1. PMID 11433040, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MFA2 mRNA was more rapidly deadenylated as well as significantly stabilized in the ccr4 deadenylation mutant in the edc3 lsm4C background. These results suggest a role for these decapping factors in stabilizing mRNA and may implicate P bodies as sites of reduced mRNA degradation.
      Title: An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress.
    2. MFA2 mRNAs are transported to the shmoo tip, in complex with processing body-like particles, where they are locally translated.
      Title: Pheromone-encoding mRNA is transported to the yeast mating projection by specific RNP granules.
    3. post-UV histone modifications and chromatin remodelling at the repressed MFA2 promoter do not activate MFA2 transcription, nor do they require damage recognition by Rad4p or Rad14p
      Title: Histone acetylation, chromatin remodelling and nucleotide excision repair: hint from the study on MFA2 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mating pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mating pheromone activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pheromone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mating pheromone a
    NP_014254.1
    • Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      352414..352530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182983.1 → NP_014254.1  TPA: mating pheromone a [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014254.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W138, P34166
      UniProtKB/TrEMBL
      A6ZRT9, B3LP00, C7GXU5, C8ZG84, G2WLW2, N1NXD7
      Conserved Domains (1) summary
      pfam17317
      Location:1 → 38
      MFA1_2; Mating hormone A-factor 1_2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34166.1

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