HFA1 acetyl-CoA carboxylase HFA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HFA1
Official Full Name: acetyl-CoA carboxylase HFA1
Primary source: SGD:S000004820
Locus tag: YMR207C
See related: AllianceGenome:SGD:S000004820; FungiDB:YMR207C; VEuPathDB:YMR207C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables acetyl-CoA carboxylase activity. Involved in long-chain fatty acid biosynthetic process. Located in mitochondrion. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HFA1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (677193..683564, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expression and evolution of the non-canonically translated yeast mitochondrial acetyl-CoA carboxylase Hfa1p
Title: Expression and evolution of the non-canonically translated yeast mitochondrial acetyl-CoA carboxylase Hfa1p.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables acetyl-CoA carboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables biotin carboxylase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetyl-CoA carboxylase HFA1

NP_013934.1

EC 6.3.4.14

EC 6.4.1.2

Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

677193..683564 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182714.1 → NP_013934.1 TPA: acetyl-CoA carboxylase HFA1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013934.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NXK1

Conserved Domains (8) summary

cd06850
Location:621 → 686

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

COG0439
Location:1 → 488

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:505 → 688

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00289
Location:1 → 106

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam01039
Location:1469 → 2026

Carboxyl_trans; Carboxyl transferase domain

pfam02785
Location:375 → 481

Biotin_carb_C; Biotin carboxylase C-terminal domain

pfam08326
Location:687 → 1371

ACC_central; Acetyl-CoA carboxylase, central region

cl17255
Location:111 → 338

ATP-grasp_4; ATP-grasp domain