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    MED11 Med11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED11
    Official Full Name
    Med11p
    Primary source
    SGD:S000004718
    Locus tag
    YMR112C
    See related
    AllianceGenome:SGD:S000004718; FungiDB:YMR112C; VEuPathDB:YMR112C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables TFIIH-class transcription factor complex binding activity and transcription coactivator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MED11 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (494100..494495, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hexadecenal dehydrogenase Neighboring gene Euc1p Neighboring gene dihydrofolate synthase Neighboring gene putative peptide hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975
    2. Architecture of the Mediator head module. Imasaki T, et al. Nature, 2011 Jul 3. PMID 21725323, Free PMC Article
    3. Mediator structural conservation and implications for the regulation mechanism. Cai G, et al. Structure, 2009 Apr 15. PMID 19368889, Free PMC Article
    4. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Seizl M, et al. Nucleic Acids Res, 2011 Aug. PMID 21498544, Free PMC Article
    5. The classical srb4-138 mutant allele causes dissociation of yeast Mediator. Linder T, et al. Biochem Biophys Res Commun, 2006 Oct 27. PMID 16962561

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables TFIIH-class transcription factor complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Med11p
    NP_013830.1
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      494100..494495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182612.1 → NP_013830.1  TPA: Med11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A6ZMG9, B3LM03, C7GW97, C8ZEW5, G2WKG2, N1NYD6
      Conserved Domains (1) summary
      pfam10280
      Location:23 → 125
      Med11; Mediator complex protein
    Nucleotide Protein
    Heading Accession and Version

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