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    UNG1 uracil-DNA glycosylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UNG1
    Official Full Name
    uracil-DNA glycosylase
    Primary source
    SGD:S000004483
    Locus tag
    YML021C
    See related
    AllianceGenome:SGD:S000004483; FungiDB:YML021C; VEuPathDB:YML021C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables uracil DNA N-glycosylase activity. Involved in DNA repair. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UNG1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (229734..230813, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Smc5-Smc6 complex subunit NSE5 Neighboring gene adenine phosphoribosyltransferase APT1 Neighboring gene uncharacterized protein Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair. Impellizzeri KJ, et al. J Bacteriol, 1991 Nov. PMID 1938887, Free PMC Article
    2. High rate of starvation-associated mutagenesis in Ung(-) yeast caused by the overproduction of human activation-induced deaminase. Lucaccioni A, et al. Curr Genet, 2007 Nov. PMID 17934734
    3. hSMUG1 can functionally compensate for Ung1 in the yeast Saccharomyces cerevisiae. Elateri I, et al. DNA Repair (Amst), 2003 Mar 1. PMID 12547394
    4. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Chatterjee A, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812822, Free PMC Article
    5. Microfluidic platform for monitoring Saccharomyces cerevisiae mutation accumulation. Sipos EH, et al. Lab Chip, 2021 Jun 15. PMID 33960358

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uracil DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uracil DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation via deaminated base removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uracil-DNA glycosylase
    NP_013691.1
    • Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      229734..230813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182379.1 → NP_013691.1  TPA: uracil-DNA glycosylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF3, E9P912, P12887
      UniProtKB/TrEMBL
      A6ZM41, B3LLN1, B5VPA5, G2WK31, N1NYJ1
      Conserved Domains (2) summary
      COG0692
      Location:100 → 337
      Ung; Uracil DNA glycosylase [Replication, recombination and repair]
      cd10027
      Location:160 → 164
      UDG-F1-like; motif A [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12887.1

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