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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029940.2 RefSeqGene
- Range
-
5012..126571
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001109754.4 → NP_001103224.1 receptor-type tyrosine-protein phosphatase beta isoform a
See identical proteins and their annotated locations for NP_001103224.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
- Source sequence(s)
-
AC025569, AI688145, BC051329, BC101679, BC143360, BQ710210, DN999550
- Consensus CDS
-
CCDS44943.1
- UniProtKB/TrEMBL
-
Q6MZF6
- Related
- ENSP00000334928.6, ENST00000334414.11
- Conserved Domains (5) summary
-
- smart00194
Location:1920 → 2178
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1947 → 2178
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:507 → 582
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- cd00161
Location:22 → 94
- RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
- pfam00041
Location:1480 → 1562
- fn3; Fibronectin type III domain
-
NM_001206971.3 → NP_001193900.1 receptor-type tyrosine-protein phosphatase beta isoform c precursor
See identical proteins and their annotated locations for NP_001193900.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
- Source sequence(s)
-
AC025569, AC083809, AI688145, BC143360, BQ710210, X54131
- Consensus CDS
-
CCDS55845.1
- UniProtKB/TrEMBL
-
Q6MZF6
- Related
- ENSP00000447302.1, ENST00000550857.5
- Conserved Domains (4) summary
-
- smart00194
Location:1612 → 1870
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1639 → 1870
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:289 → 364
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:1172 → 1254
- fn3; Fibronectin type III domain
-
NM_001206972.3 → NP_001193901.1 receptor-type tyrosine-protein phosphatase beta isoform d precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
- Source sequence(s)
-
AC025569, AC083809, AI688145, BC101679, BC143356, BC143360, BQ710210, X54131
- Consensus CDS
-
CCDS55846.1
- UniProtKB/TrEMBL
-
Q6MZF6
- Related
- ENSP00000438927.1, ENST00000538708.5
- Conserved Domains (4) summary
-
- smart00194
Location:1612 → 1870
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1639 → 1870
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:289 → 364
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:1172 → 1254
- fn3; Fibronectin type III domain
-
NM_001330204.2 → NP_001317133.1 receptor-type tyrosine-protein phosphatase beta isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting isoform (e) is shorter but has the same N- and C-termini compared to isoform a.
- Source sequence(s)
-
AC025569, AI688145, AK097371, BC051329, BC101679, BC143360, BQ710210, CR749546, DN999550
- Consensus CDS
-
CCDS81713.1
- UniProtKB/TrEMBL
- F8VU56, Q6MZF6
- Related
- ENSP00000448058.1, ENST00000550358.5
-
NM_002837.6 → NP_002828.3 receptor-type tyrosine-protein phosphatase beta isoform b precursor
See identical proteins and their annotated locations for NP_002828.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
- Source sequence(s)
-
AC025569, AC083809, AI688145, BC101679, BC143360, BQ710210, X54131
- Consensus CDS
-
CCDS44944.1
- UniProtKB/Swiss-Prot
- B7ZKS8, B7ZKT0, C9JX87, F5H3G6, P23467, Q14D85, Q3MIV7
- UniProtKB/TrEMBL
-
Q6MZF6
- Related
- ENSP00000261266.5, ENST00000261266.9
- Conserved Domains (4) summary
-
- smart00194
Location:1702 → 1960
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1729 → 1960
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:289 → 364
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:1262 → 1344
- fn3; Fibronectin type III domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
70515870..70637429 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011538614.2 → XP_011536916.1 receptor-type tyrosine-protein phosphatase beta isoform X2
- UniProtKB/TrEMBL
-
Q6MZF6
- Conserved Domains (5) summary
-
- smart00194
Location:1832 → 2090
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1859 → 2090
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:507 → 582
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- cd00161
Location:22 → 94
- RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
- pfam00041
Location:1392 → 1474
- fn3; Fibronectin type III domain
-
XM_006719528.2 → XP_006719591.1 receptor-type tyrosine-protein phosphatase beta isoform X1
- UniProtKB/TrEMBL
-
Q6MZF6
- Conserved Domains (5) summary
-
- smart00194
Location:1920 → 2178
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1947 → 2178
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:507 → 582
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- cd00161
Location:22 → 94
- RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
- pfam00041
Location:1480 → 1562
- fn3; Fibronectin type III domain
-
XM_006719529.5 → XP_006719592.1 receptor-type tyrosine-protein phosphatase beta isoform X3
- UniProtKB/TrEMBL
-
Q6MZF6
- Conserved Domains (4) summary
-
- smart00194
Location:1702 → 1960
- PTPc; Protein tyrosine phosphatase, catalytic domain
- cd00047
Location:1729 → 1960
- PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
- cd00063
Location:289 → 364
- FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
- pfam00041
Location:1262 → 1344
- fn3; Fibronectin type III domain
-
XM_017019724.1 → XP_016875213.1 receptor-type tyrosine-protein phosphatase beta isoform X4
RNA
-
XR_944651.2 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
70495299..70616833 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054372721.1 → XP_054228696.1 receptor-type tyrosine-protein phosphatase beta isoform X2
- UniProtKB/TrEMBL
-
Q6MZF6
-
XM_054372720.1 → XP_054228695.1 receptor-type tyrosine-protein phosphatase beta isoform X1
- UniProtKB/TrEMBL
-
Q6MZF6
-
XM_054372722.1 → XP_054228697.1 receptor-type tyrosine-protein phosphatase beta isoform X3
- UniProtKB/TrEMBL
-
Q6MZF6
-
XM_054372723.1 → XP_054228698.1 receptor-type tyrosine-protein phosphatase beta isoform X4
RNA
-
XR_008488648.1 RNA Sequence