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    PXK PX domain containing serine/threonine kinase like [ Homo sapiens (human) ]

    Gene ID: 54899, updated on 9-Dec-2024

    Summary

    Official Symbol
    PXKprovided by HGNC
    Official Full Name
    PX domain containing serine/threonine kinase likeprovided by HGNC
    Primary source
    HGNC:HGNC:23326
    See related
    Ensembl:ENSG00000168297 MIM:611450; AllianceGenome:HGNC:23326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLOB; MONAKA
    Summary
    This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PXK in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (58332892..58426127)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (58373299..58466504)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58318619..58411854)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58222930-58223869 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58276464-58277147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:58298051-58298552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:58307710-58308471 Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14488 Neighboring gene Sharpr-MPRA regulatory region 6112 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20010 Neighboring gene uncharacterized LOC105377106 Neighboring gene MPRA-validated peak4672 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:58363583-58363810 Neighboring gene WDR53 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58383233-58383732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20012 Neighboring gene uncharacterized LOC107986092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14489 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58420577-58421186 Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14490 Neighboring gene potassium channel tetramerization domain containing 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ20335

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables ATP binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables nucleotide binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in modulation of chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of monoatomic ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    PX domain-containing protein kinase-like protein
    Names
    PX ser/thr kinase v2
    PX serine/threonine kinase
    modulator of Na,K-ATPase long form

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289095.2NP_001276024.1  PX domain-containing protein kinase-like protein isoform b

      See identical proteins and their annotated locations for NP_001276024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform b (also known as isoform 2), which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK131385, AL137938, AY437879, DA296189
      Consensus CDS
      CCDS74954.1
      UniProtKB/TrEMBL
      A0A0C4DG95, B4DID9
      Related
      ENSP00000419049.1, ENST00000479241.5
      Conserved Domains (2) summary
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    2. NM_001289096.2NP_001276025.1  PX domain-containing protein kinase-like protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive, alternate, in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform c (also known as isoform 3), which is shorter than isoform a.
      Source sequence(s)
      AL137938, AY274811, AY437879, BG613223, DA296189
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    3. NM_001289098.2NP_001276027.1  PX domain-containing protein kinase-like protein isoform d

      See identical proteins and their annotated locations for NP_001276027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform d (also known as isoform 4), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 4 and 8 both encode the same isoform (d).
      Source sequence(s)
      AK131385, AK296034, AL137938, DQ124708, HY164612
      Consensus CDS
      CCDS74952.1
      UniProtKB/TrEMBL
      B4DID9
      Related
      ENSP00000373222.4, ENST00000383716.7
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    4. NM_001289099.2NP_001276028.1  PX domain-containing protein kinase-like protein isoform e

      See identical proteins and their annotated locations for NP_001276028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform e (also known as isoform 5), which has a shorter N-terminus, compared to isoform a. Variants 5 and 9 both encode the same isoform (e).
      Source sequence(s)
      AK131385, AL137938, AY847220, HY164612
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (3) summary
      cd22062
      Location:462492
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001289100.2NP_001276029.1  PX domain-containing protein kinase-like protein isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two consecutive, alternate, in-frame exons in the 5' coding region and contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform f (also known as isoform 6), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 6 and 10 both encode the same isoform (f).
      Source sequence(s)
      AK295542, AK296034, AL137938, AY274811, DA296189
      Consensus CDS
      CCDS74955.1
      UniProtKB/TrEMBL
      B4DID9, E9PD56
      Related
      ENSP00000417903.1, ENST00000463280.5
      Conserved Domains (3) summary
      COG0515
      Location:153459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    6. NM_001289101.2NP_001276030.1  PX domain-containing protein kinase-like protein isoform g

      See identical proteins and their annotated locations for NP_001276030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform g (also known as isoform 7), which is shorter at the N-terminus, compared to isoform a. Variants 7 and 11 both encode the same isoform (g).
      Source sequence(s)
      AK131385, AK296215, AL137938, AY274811, DA296189
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:408438
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61208
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001349488.2NP_001336417.1  PX domain-containing protein kinase-like protein isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS74952.1
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    8. NM_001349489.2NP_001336418.1  PX domain-containing protein kinase-like protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 5, encodes isoform e.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (3) summary
      cd22062
      Location:462492
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115262
      PKc_like; Protein Kinases, catalytic domain
    9. NM_001349490.2NP_001336419.1  PX domain-containing protein kinase-like protein isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 6, encodes isoform f.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS74955.1
      UniProtKB/TrEMBL
      B4DID9, E9PD56
      Conserved Domains (3) summary
      COG0515
      Location:153459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    10. NM_001349491.2NP_001336420.1  PX domain-containing protein kinase-like protein isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 7, encodes isoform g.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:408438
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61208
      PKc_like; Protein Kinases, catalytic domain
    11. NM_001349492.2NP_001336421.1  PX domain-containing protein kinase-like protein isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes the longest isoform (h).
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    12. NM_001349493.2NP_001336422.1  PX domain-containing protein kinase-like protein isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform i.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cl21453
      Location:198345
      PKc_like; Protein Kinases, catalytic domain
    13. NM_001349494.2NP_001336423.1  PX domain-containing protein kinase-like protein isoform j

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) encodes isoform j.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:529559
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:182329
      PKc_like; Protein Kinases, catalytic domain
    14. NM_001349495.2NP_001336424.1  PX domain-containing protein kinase-like protein isoform k

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) encodes isoform k.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:528558
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:182329
      PKc_like; Protein Kinases, catalytic domain
    15. NM_001349496.2NP_001336425.1  PX domain-containing protein kinase-like protein isoform jj

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) encodes isoform jj.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      COG0515
      Location:169475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    16. NM_001349497.2NP_001336426.1  PX domain-containing protein kinase-like protein isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) encodes isoform l.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    17. NM_001349498.1NP_001336427.1  PX domain-containing protein kinase-like protein isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) encodes isoform m.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      W5RWD6
      Conserved Domains (3) summary
      cd06871
      Location:15112
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:166472
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:178325
      PKc; Catalytic domain of Protein Kinases
    18. NM_001349499.2NP_001336428.1  PX domain-containing protein kinase-like protein isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) encodes isoform n.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS87097.1
      UniProtKB/TrEMBL
      W5RWE6
      Related
      ENSP00000305045.6, ENST00000302779.9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186526
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    19. NM_001349500.2NP_001336429.1  PX domain-containing protein kinase-like protein isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) encodes isoform o.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    20. NM_001349501.2NP_001336430.1  PX domain-containing protein kinase-like protein isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) encodes isoform p.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170510
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182329
      PKc; Catalytic domain of Protein Kinases
    21. NM_001349502.2NP_001336431.1  PX domain-containing protein kinase-like protein isoform q

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) encodes isoform q.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      COG0515
      Location:169509
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    22. NM_001349503.2NP_001336432.1  PX domain-containing protein kinase-like protein isoform r

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variant 26, encodes isoform r.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    23. NM_001349504.2NP_001336433.1  PX domain-containing protein kinase-like protein isoform kk

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform kk.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    24. NM_001349506.2NP_001336435.1  PX domain-containing protein kinase-like protein isoform kk

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform kk.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    25. NM_001349507.2NP_001336436.1  PX domain-containing protein kinase-like protein isoform r

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variant 23, encodes isoform r.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    26. NM_001349508.2NP_001336437.1  PX domain-containing protein kinase-like protein isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27), as well as variant 28, encodes isoform s.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    27. NM_001349509.2NP_001336438.1  PX domain-containing protein kinase-like protein isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variant 27, encodes isoform s.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    28. NM_001349510.2NP_001336439.1  PX domain-containing protein kinase-like protein isoform t

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) encodes isoform t.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170476
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182329
      PKc; Catalytic domain of Protein Kinases
    29. NM_001349511.2NP_001336440.1  PX domain-containing protein kinase-like protein isoform u

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30) encodes isoform u.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:182329
      PKc; Catalytic domain of Protein Kinases
    30. NM_001349512.2NP_001336441.1  PX domain-containing protein kinase-like protein isoform ll

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31) encodes isoform ll.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170476
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182329
      PKc; Catalytic domain of Protein Kinases
    31. NM_001349513.2NP_001336442.1  PX domain-containing protein kinase-like protein isoform mm

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32) encodes isoform mm.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    32. NM_001349514.2NP_001336443.1  PX domain-containing protein kinase-like protein isoform nn

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33) encodes isoform nn.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS87098.1
      UniProtKB/TrEMBL
      B4DID9, H7BYG4
      Related
      ENSP00000373221.4, ENST00000383715.8
      Conserved Domains (3) summary
      COG0515
      Location:169475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    33. NM_001349515.2NP_001336444.1  PX domain-containing protein kinase-like protein isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34) encodes isoform v.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    34. NM_001349516.2NP_001336445.1  PX domain-containing protein kinase-like protein isoform oo

      Status: VALIDATED

      Description
      Transcript Variant: This variant (35) encodes isoform oo.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:182329
      PKc; Catalytic domain of Protein Kinases
    35. NM_001349517.2NP_001336446.1  PX domain-containing protein kinase-like protein isoform pp

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36) encodes isoform pp.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:169475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    36. NM_001349518.2NP_001336447.1  PX domain-containing protein kinase-like protein isoform w

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37) encodes isoform w.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:181328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    37. NM_001349519.2NP_001336448.1  PX domain-containing protein kinase-like protein isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38), as well as variant 39, encodes isoform x.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186493
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    38. NM_001349520.2NP_001336449.1  PX domain-containing protein kinase-like protein isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39), as well as variant 38, encodes isoform x.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186493
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    39. NM_001349521.2NP_001336450.1  PX domain-containing protein kinase-like protein isoform qq

      Status: VALIDATED

      Description
      Transcript Variant: This variant (40) encodes isoform qq.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    40. NM_001349522.2NP_001336451.1  PX domain-containing protein kinase-like protein isoform y

      Status: VALIDATED

      Description
      Transcript Variant: This variant (41) encodes isoform y.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:153459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    41. NM_001349524.2NP_001336453.1  PX domain-containing protein kinase-like protein isoform z

      Status: VALIDATED

      Description
      Transcript Variant: This variant (42) encodes isoform z.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:165312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1399
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    42. NM_001349525.2NP_001336454.1  PX domain-containing protein kinase-like protein isoform aa

      Status: VALIDATED

      Description
      Transcript Variant: This variant (43) encodes isoform aa.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      COG0515
      Location:49355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    43. NM_001349526.2NP_001336455.1  PX domain-containing protein kinase-like protein isoform bb

      Status: VALIDATED

      Description
      Transcript Variant: This variant (44) encodes isoform bb.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:407437
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61208
      PKc_like; Protein Kinases, catalytic domain
    44. NM_001349527.2NP_001336456.1  PX domain-containing protein kinase-like protein isoform cc

      Status: VALIDATED

      Description
      Transcript Variant: This variant (45) encodes isoform cc.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198345
      PKc; Catalytic domain of Protein Kinases
    45. NM_001349528.2NP_001336457.1  PX domain-containing protein kinase-like protein isoform dd

      Status: VALIDATED

      Description
      Transcript Variant: This variant (46), as well as variant 47, encodes isoform dd.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    46. NM_001349529.2NP_001336458.1  PX domain-containing protein kinase-like protein isoform dd

      Status: VALIDATED

      Description
      Transcript Variant: This variant (47), as well as variant 46, encodes isoform dd.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    47. NM_001349530.2NP_001336459.1  PX domain-containing protein kinase-like protein isoform ee

      Status: VALIDATED

      Description
      Transcript Variant: This variant (48) encodes isoform ee.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    48. NM_001349531.2NP_001336460.1  PX domain-containing protein kinase-like protein isoform rr

      Status: VALIDATED

      Description
      Transcript Variant: This variant (49) encodes isoform rr.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:149
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    49. NM_001349532.2NP_001336461.1  PX domain-containing protein kinase-like protein isoform ff

      Status: VALIDATED

      Description
      Transcript Variant: This variant (50) encodes isoform ff.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      COG0515
      Location:49389
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    50. NM_001349533.2NP_001336462.1  PX domain-containing protein kinase-like protein isoform gg

      Status: VALIDATED

      Description
      Transcript Variant: This variant (51), as well as variant 52, encodes isoform gg.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    51. NM_001349534.2NP_001336463.1  PX domain-containing protein kinase-like protein isoform gg

      Status: VALIDATED

      Description
      Transcript Variant: This variant (52), as well as variant 51, encodes isoform gg.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    52. NM_001349535.2NP_001336464.1  PX domain-containing protein kinase-like protein isoform hh

      Status: VALIDATED

      Description
      Transcript Variant: This variant (53), as well as variant 54, encodes isoform hh.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    53. NM_001349536.2NP_001336465.1  PX domain-containing protein kinase-like protein isoform hh

      Status: VALIDATED

      Description
      Transcript Variant: This variant (54), as well as variant 53, encodes isoform hh.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    54. NM_001349537.2NP_001336466.1  PX domain-containing protein kinase-like protein isoform ss

      Status: VALIDATED

      Description
      Transcript Variant: This variant (55), as well as variant 56, encodes isoform ss.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    55. NM_001349538.2NP_001336467.1  PX domain-containing protein kinase-like protein isoform ss

      Status: VALIDATED

      Description
      Transcript Variant: This variant (56), as well as variant 55, encodes isoform ss.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    56. NM_001349539.2NP_001336468.1  PX domain-containing protein kinase-like protein isoform ii

      Status: VALIDATED

      Description
      Transcript Variant: This variant (57), as well as variant 58, encodes isoform ii.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    57. NM_001349540.2NP_001336469.1  PX domain-containing protein kinase-like protein isoform ii

      Status: VALIDATED

      Description
      Transcript Variant: This variant (58), as well as variant 57, encodes isoform ii.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61208
      PKc; Catalytic domain of Protein Kinases
    58. NM_017771.5NP_060241.2  PX domain-containing protein kinase-like protein isoform a

      See identical proteins and their annotated locations for NP_060241.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a (also known as isoform 1).
      Source sequence(s)
      AK296034, AL137938, AY274811, DQ124707, DQ124708, HY164612
      Consensus CDS
      CCDS2889.1
      UniProtKB/Swiss-Prot
      Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q7Z7A4, Q96CA3, Q96R07, Q9NXB8
      Related
      ENSP00000348472.2, ENST00000356151.7
      Conserved Domains (3) summary
      cd06871
      Location:13132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:545575
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:198345
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_146193.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098479, AC135507
    2. NR_146194.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098479, AC135507

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      58332892..58426127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      58373299..58466504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)