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    PRM1 pheromone-regulated protein PRM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRM1
    Official Full Name
    pheromone-regulated protein PRM1
    Primary source
    SGD:S000005223
    Locus tag
    YNL279W
    See related
    AllianceGenome:SGD:S000005223; FungiDB:YNL279W; VEuPathDB:YNL279W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in plasma membrane fusion involved in cytogamy. Located in mating projection tip. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRM1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (110917..112902)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hch1p Neighboring gene delta(14)-sterol reductase Neighboring gene Caf120p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prm1 prevents contact-dependent lysis of yeast mating pairs. Jin H, et al. Eukaryot Cell, 2004 Dec. PMID 15590839, Free PMC Article
    2. Prm1 functions as a disulfide-linked complex in yeast mating. Olmo VN, et al. J Biol Chem, 2010 Jan 22. PMID 19933274, Free PMC Article
    3. The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion. Engel A, et al. PLoS One, 2010 May 11. PMID 20485669, Free PMC Article
    4. The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. Heiman MG, et al. J Cell Biol, 2007 Jan 15. PMID 17210951, Free PMC Article
    5. Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis. Potelle S, et al. Hum Mol Genet, 2016 Apr 15. PMID 27008884

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cells lacking both ECM22 and UPC2 display strong mating defects whereas deletion of either gene has no effect. Ecm22 and Upc2 positively regulate basal expression of PRM1 and PRM4. These genes are strongly induced in response to mating pheromone, which is also largely dependent on ECM22 and UPC2.
      Title: Ecm22 and Upc2 regulate yeast mating through control of expression of the mating genes PRM1 and PRM4.
    2. Cys(120) in loop 1 and Cys(545) in loop 2 form disulfide cross-links in the Prm1 homodimer and are required for fusion activity
      Title: Prm1 functions as a disulfide-linked complex in yeast mating.
    3. Kex2 and Kex1 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both.
      Title: The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
    4. Prm1 protein stabilizes the membrane fusion event of yeast mating
      Title: Prm1 prevents contact-dependent lysis of yeast mating pairs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in plasma membrane fusion involved in cytogamy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane fusion involved in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    is_active_in mating projection tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pheromone-regulated protein PRM1
    NP_014120.1
    • Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      110917..112902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183117.1 → NP_014120.1  TPA: pheromone-regulated protein PRM1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R5, P53835
      UniProtKB/TrEMBL
      B3LPB8, N1NWX5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53835.1

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