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    HOS3 histone deacetylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HOS3
    Official Full Name
    histone deacetylase
    Primary source
    SGD:S000006037
    Locus tag
    YPL116W
    See related
    AllianceGenome:SGD:S000006037; FungiDB:YPL116W; VEuPathDB:YPL116W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histone deacetylase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Located in several cellular components, including cellular bud neck; nucleus; and prospore membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HOS3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (329606..331699)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene isopentenyl-diphosphate delta-isomerase IDI1 Neighboring gene GTPase-activating protein BEM3 Neighboring gene glyoxylate reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Chou CC, et al. Mol Cell, 2008 Sep 5. PMID 18775325, Free PMC Article
    2. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. Carmen AA, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10535926, Free PMC Article
    3. Structural characterization of fungus-specific histone deacetylase Hos3 provides insights into developing selective inhibitors with antifungal activity. Pang N, et al. J Biol Chem, 2022 Jul. PMID 35623387, Free PMC Article
    4. Polyamines inhibit the yeast histone deacetylase. Vu QA, et al. FEBS Lett, 1987 Aug 10. PMID 3301411
    5. Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10. Ahn SH, et al. Mol Cell, 2006 Oct 20. PMID 17052455

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone H3K14 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K12 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K16 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K5 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K8 deacetylase activity, hydrolytic mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in prospore membrane HDA PubMed 

    General protein information

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    Preferred Names
    histone deacetylase
    NP_015209.1
    • Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      329606..331699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183930.1 → NP_015209.1  TPA: histone deacetylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015209.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Q2, Q02959
      UniProtKB/TrEMBL
      A6ZWD6, B3LKV8, B5VT50, C7GJ69, C8ZIR4, G2WP66, N1NX39
      Conserved Domains (1) summary
      cd09998
      Location:47 → 435
      HDAC_Hos3; Class II histone deacetylases Hos3 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02959.1

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