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    wrapper wrapper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrapperprovided by FlyBase
    Official Full Name
    wrapperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025878
    Locus tag
    Dmel_CG10382
    See related
    AllianceGenome:FB:FBgn0025878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10382; CT19059; Dmel\CG10382; Wr; Wrapper
    Summary
    Predicted to enable axon guidance receptor activity. Involved in axon development; axon ensheathment; and glial cell apoptotic process. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including adult head; central brain primordium; ganglia; glial cell; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wrapper in Genome Data Viewer
    Location:
    58D4-58D4; 2-99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22379637..22382675)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18267142..18270180)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44759 Neighboring gene long non-coding RNA:CR45327 Neighboring gene Rtf1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44757 Neighboring gene babos

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Shep and C. elegans SUP-26 are RNA-binding proteins that play diverse roles in nervous system development. Schachtner LT, et al. Dev Genes Evol, 2015 Nov. PMID 26271810
    2. A versatile genetic tool to study midline glia function in the Drosophila CNS. Banerjee S, et al. Dev Biol, 2017 Sep 1. PMID 28602954, Free PMC Article
    3. Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions. Slováková J, et al. Development, 2011 Apr. PMID 21389054
    4. Lola regulates midline crossing of CNS axons in Drosophila. Crowner D, et al. Development, 2002 Mar. PMID 11880341
    5. Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper. Stork T, et al. Development, 2009 Apr. PMID 19261699

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV.
      Title: Canoe functions at the CNS midline glia in a complex with Shotgun and Wrapper-Nrx-IV during neuron-glia interactions.
    2. Although both Neurexin IV isoforms are able to bind Wrapper, the neuronal isoform has a higher affinity for Wrapper
      Title: Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper.
    3. neuronal-expressed Neurexin IV and midline glial-expressed Wrapper act as heterophilic adhesion molecules that mediate multiple cellular events involved in glia-neuron interactions
      Title: Neurexin IV and Wrapper interactions mediate Drosophila midline glial migration and axonal ensheathment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables axon guidance receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    wrapper
    Names
    CG10382-PA
    wrapper-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22379637..22382675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058056.4 → NP_477404.1  wrapper [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961W0, Q9W260, Q9XZB7
      Related
      FBpp0071732
      Conserved Domains (5) summary
      smart00408
      Location:236 → 314
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:145 → 218
      IG_like; Immunoglobulin like
      cd00063
      Location:339 → 431
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:224 → 323
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:147 → 219
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W260 Q9W260
    Q9XZB7 Q9XZB7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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