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    Tsp68C Tetraspanin 68C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp68Cprovided by FlyBase
    Official Full Name
    Tetraspanin 68Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043550
    Locus tag
    Dmel_CG32136
    See related
    AllianceGenome:FB:FBgn0043550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32136; Dm.Tsp68C; Dmel\CG32136; Tsp68c
    Summary
    Involved in hemopoiesis. Located in perinuclear region of cytoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp68C in Genome Data Viewer
    Location:
    70C4-70C4; 3-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13843656..13845316)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13836756..13838416)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hemolectin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Increased expression of Drosophila tetraspanin, Tsp68C, suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes. Sinenko SA, et al. Oncogene, 2004 Dec 2. PMID 15480416
    2. Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. Le Bras S, et al. J Cell Sci, 2012 Oct 15. PMID 22825875
    3. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    4. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467
    5. Changes in organelle position and epithelial architecture associated with loss of CrebA. Fox RM, et al. Biol Open, 2015 Feb 13. PMID 25681391, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin 68C
    Names
    CG32136-PA
    CG32136-PC
    Tetraspanin68C
    Tsp68C-PA
    Tsp68C-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13843656..13845316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168558.2 → NP_729926.1  tetraspanin 68C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3R4, Q8IQK8, Q8IQK9
      Related
      FBpp0075493
      Conserved Domains (2) summary
      cd03127
      Location:117 → 241
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 267
      Tetraspannin; Tetraspanin family

    2. NM_168559.2 → NP_729927.2  tetraspanin 68C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729927.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V3R4, Q8IQK8, Q8IQK9
      Conserved Domains (2) summary
      cd03127
      Location:117 → 241
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 267
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQK9 Q8IQK9

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