babo baboon [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: baboprovided by FlyBase
Official Full Name: baboonprovided by FlyBase
Primary source: FLYBASE:FBgn0011300
Locus tag: Dmel_CG8224
See related: AllianceGenome:FB:FBgn0011300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Atf1; Atr-1; ATR-1; atr-I; Atr-I; ATR-I; Atr45A; AtrI; Bab; Babo; BABO; BaboA; Baboon; CG8224; Dmel\CG8224; Gprk-3; Gprk3; l(2)44Fd; l(2)k16912; STK-E
Summary: Enables activin binding activity and activin receptor activity, type I. Involved in several processes, including determination of adult lifespan; imaginal disc morphogenesis; and nervous system development. Located in plasma membrane. Part of activin receptor complex. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval gut; female germline cell; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); gastrointestinal system cancer (multiple); and malignant mesothelioma. Orthologous to human ACVR1B (activin A receptor type 1B); ACVR1C (activin A receptor type 1C); and TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44F11-44F12; 2-59 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8952339..8962796)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4839844..4850301)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Visualization of Endogenous Type I TGF-beta Receptor Baboon in the Drosophila Brain.
Title: Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
Data show that dSmad2 directly influences Baboon's phosphorylation of Mad.
Title: R-Smad competition controls activin receptor output in Drosophila.
Study shows that the Daw/Babo pathway acts upstream of gbb, and is involved in maintenance of muscle gbb expression.
Title: Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction.
Dawdle, one of four Activin-type ligands in Drosophila, preferentially signals through Babo(c), one of three isoforms of the Activin Type-I receptor that are expressed during development.
Title: The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon.
Dad inhibited Saxophone and Thickveins but not Baboon.
Title: Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis.
Title: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables activin binding	IPI Inferred from Physical Interaction more info	PubMed
enables activin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type I	IBA Inferred from Biological aspect of Ancestor more info
enables activin receptor activity, type I	IDA Inferred from Direct Assay more info	PubMed
enables activin receptor activity, type I	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_positive_effect determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye-antennal disc morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of imaginal disc-derived wing size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of activin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of activin receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: baboon

Names: CG8224-PA; CG8224-PB; CG8224-PC; G protein-coupled receptor kinase 3; activin A receptor 45A; activin type I receptor; babo; babo-PA; babo-PB; babo-PC; baboa

NP_001163092.1

EC 2.7.11.1

EC 2.7.11.30

NP_476999.1

EC 2.7.11.1

EC 2.7.11.30

NP_477000.1

EC 2.7.11.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8952339..8962796

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057651.4 → NP_476999.1 baboon, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476999.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7L8, Q23975

Related

FBpp0087739

Conserved Domains (4) summary

smart00467
Location:294 → 324

GS; GS motif

cd14143
Location:328 → 615

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:127 → 214

Activin_recp; Activin types I and II receptor domain

pfam07714
Location:324 → 611

Pkinase_Tyr; Protein tyrosine kinase
NM_057652.4 → NP_477000.1 baboon, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477000.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7L9, Q23975

Related

FBpp0087740

Conserved Domains (4) summary

smart00467
Location:273 → 303

GS; GS motif

cd14143
Location:307 → 594

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:127 → 204

Activin_recp; Activin types I and II receptor domain

pfam07714
Location:303 → 590

Pkinase_Tyr; Protein tyrosine kinase
NM_001169621.2 → NP_001163092.1 baboon, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163092.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23975, Q7YU60

Conserved Domains (4) summary

smart00467
Location:267 → 297

GS; GS motif

cd14143
Location:301 → 588

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:127 → 196

Activin_recp; Activin types I and II receptor domain

pfam07714
Location:297 → 584

Pkinase_Tyr; Protein tyrosine kinase