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    mei-9 meiotic 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mei-9provided by FlyBase
    Official Full Name
    meiotic 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0002707
    Locus tag
    Dmel_CG3697
    See related
    AllianceGenome:FB:FBgn0002707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3697; DhR1; Dmel\CG3697; DmXPF; Mei-9; MEI-9; mei9; mus(1)110; mus110; Rad1p; xpf/mei-9
    Summary
    Enables protein heterodimerization activity. Involved in DNA metabolic process; female meiosis chromosome segregation; and oocyte fate determination. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mei-9 in Genome Data Viewer
    Location:
    4B6-4B6; 1-7 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4314230..4318801, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4208263..4212834, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44957 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46156 Neighboring gene Nucleolar protein 66 Neighboring gene mitochondrial ribosomal protein L33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster. Baker BS, et al. Basic Life Sci, 1980. PMID 6783029
    2. Induced crossing-over in Drosophila melanogaster germ cells of DNA repair-proficient and repair-deficient (mei-9L1) males following larval feeding with 5-azacytidine and mitomycin C. Pontecorvo G, et al. Mutat Res, 1992 Apr. PMID 1373843
    3. Apurinic endonuclease activity from wild-type and repair-deficient mei-9 Drosophila ovaries. Venugopal S, et al. Mol Gen Genet, 1990 May. PMID 1696350
    4. Reduction of spontaneous somatic mutation frequency by a low-dose X irradiation of Drosophila larvae and possible involvement of DNA single-strand damage repair. Koana T, et al. Radiat Res, 2012 Mar. PMID 22103273
    5. A U-shaped dose-response relationship between x radiation and sex-linked recessive lethal mutation in male germ cells of Drosophila. Koana T, et al. Radiat Res, 2010 Jul. PMID 20681798

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HDM, MEI-9, MUS312, and ERCC1 form a complex that resolves meiotic recombination intermediates into crossovers.
      Title: Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1.
    2. These results support a model in which MEI-9 nicks Holliday junctions to generate crossovers during meiotic recombination, and, in the absence of MEI-9 activity, the double Holliday junction intermediate instead undergoes dissolution.
      Title: Heteroduplex DNA in meiotic recombination in Drosophila mei-9 mutants.
    3. Drosophila mei-9 has roles in DNA repair and recombination, as shown by mutational analysis
      Title: Mutational analysis of the Drosophila DNA repair and recombination gene mei-9.
    4. MUS312 facilitates resolution of meiotic Holliday junction intermediates by MEI-9
      Title: Drosophila MUS312 interacts with the nucleotide excision repair endonuclease MEI-9 to generate meiotic crossovers.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleotide-excision repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiotic 9
    Names
    CG3697-PA
    CG3697-PB
    mei-9-PA
    mei-9-PB
    meiotic-9

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4314230..4318801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080329.3 → NP_525068.1  meiotic 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525068.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24087, Q8IHB9, Q9W4L3
      UniProtKB/TrEMBL
      T2FFI3
      Related
      FBpp0070624
      Conserved Domains (2) summary
      TIGR00596
      Location:122 → 923
      rad1; DNA repair protein (rad1)
      pfam02732
      Location:700 → 832
      ERCC4; ERCC4 domain

    2. NM_001297930.1 → NP_001284859.1  meiotic 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24087, Q8IHB9, Q9W4L3
      UniProtKB/TrEMBL
      T2FFI3
      Conserved Domains (2) summary
      TIGR00596
      Location:122 → 923
      rad1; DNA repair protein (rad1)
      pfam02732
      Location:700 → 832
      ERCC4; ERCC4 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24087.2 Q24087
    T2FFI3 T2FFI3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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