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    Bet5 Blocked early in transport 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bet5provided by FlyBase
    Official Full Name
    Blocked early in transport 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0260860
    Locus tag
    Dmel_CG1359
    See related
    AllianceGenome:FB:FBgn0260860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BET5; Bet5p; CG1359; Dmel\CG1359; TRAPPC1
    Summary
    Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Orthologous to human TRAPPC1 (trafficking protein particle complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bet5 in Genome Data Viewer
    Location:
    99E1-99E1; 3-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30180232..30181486)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26005954..26007208)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44262 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article
    2. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. Robinett CC, et al. J Cell Sci, 2009 Dec 15. PMID 19934220, Free PMC Article
    3. The ROP vesicle release factor is required in adult Drosophila glia for normal circadian behavior. Ng FS, et al. Front Cell Neurosci, 2015. PMID 26190976, Free PMC Article
    4. Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Ambrus AM, et al. Genetics, 2009 Sep. PMID 19546319, Free PMC Article
    5. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. Riedel F, et al. J Cell Biol, 2018 Feb 5. PMID 29273580, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    blocked early in transport 5
    Names
    BET5 ortholog
    Bet5-PA
    CG1359-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30180232..30181486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143521.2 → NP_651778.1  blocked early in transport 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VA95
      Related
      FBpp0084936
      Conserved Domains (1) summary
      pfam04099
      Location:3 → 137
      Sybindin; Sybindin-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA95 Q9VA95

    Gene LinkOut

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