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    mil milkah [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    milprovided by FlyBase
    Official Full Name
    milkahprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267366
    Locus tag
    Dmel_CG5017
    See related
    AllianceGenome:FB:FBgn0267366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5017; Dmel\CG5017; hanabi; Mil; tNAP
    Summary
    Enables histone binding activity. Involved in several processes, including male courtship behavior; memory; and nucleosome assembly. Located in Nebenkern and cytosol. Is expressed in adult head; spermatozoon; and testis. Orthologous to human NAP1L3 (nucleosome assembly protein 1 like 3) and NAP1L5 (nucleosome assembly protein 1 like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mil in Genome Data Viewer
    Location:
    98B5-98B5; 3-94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27912447..27913785)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23738169..23739507)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 98a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene Buddy of Hmr 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster]. Kuzin BA, et al. Ontogenez, 2010 Sep-Oct. PMID 21061663
    2. Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification. Kuzin BA, et al. PLoS One, 2014. PMID 24736732, Free PMC Article
    3. The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin. Kimura S, et al. Open Biol, 2016 Nov. PMID 27810970, Free PMC Article
    4. The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis. Kimura S. FEBS Lett, 2013 Apr 2. PMID 23454210
    5. Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila. Lee YC, et al. Mol Biol Evol, 2017 Feb 1. PMID 27836984, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate the essential roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in spermatogenesis
      Title: The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.
    2. Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster
      Title: [Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Nebenkern IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    milkah
    Names
    CG5017-PA
    hanabi
    mil-PA
    milkah-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27912447..27913785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143335.2 → NP_651592.2  milkah [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651592.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZC3, Q9VAZ1
      Related
      FBpp0084615
      Conserved Domains (1) summary
      pfam00956
      Location:37 → 251
      NAP; Nucleosome assembly protein (NAP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAZ1 Q9VAZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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