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    ergic53 ergic53 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44679, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ergic53provided by FlyBase
    Official Full Name
    ergic53provided by FlyBase
    Primary source
    FLYBASE:FBgn0035909
    Locus tag
    Dmel_CG6822
    See related
    AllianceGenome:FB:FBgn0035909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6822; dergic53; dERGIC53; Dmel\CG6822; ERGIC53; l(3)s1760; l(3)S1760
    Summary
    Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to several human genes including LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ergic53 in Genome Data Viewer
    Location:
    66D6-66D6; 3-26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8534977..8538013)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8528077..8531113)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase O1 Neighboring gene fear-of-intimacy Neighboring gene rhea Neighboring gene long non-coding RNA:CR43910 Neighboring gene mir-190 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lectins and traffic in the secretory pathway. Hauri H, et al. FEBS Lett, 2000 Jun 30. PMID 10878245
    2. C9orf72 Toxic Species Affect ArfGAP-1 Function. Rossi S, et al. Cells, 2023 Aug 5. PMID 37566088, Free PMC Article
    3. Talin is essential for integrin function in Drosophila. Brown NH, et al. Dev Cell, 2002 Oct. PMID 12408808
    4. The Drosophila transmembrane protein Fear-of-intimacy controls glial cell migration. Pielage J, et al. Dev Biol, 2004 Nov 1. PMID 15464587
    5. A cilia-bound unconventional secretory pathway for Drosophila odorant receptors. Dzaki N, et al. BMC Biol, 2024 Apr 12. PMID 38610043, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ergic53
    Names
    CG6822-PA
    CG6822-PB
    ergic-53
    ergic53-PA
    ergic53-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8534977..8538013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176301.2 → NP_788479.1  ergic53, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788479.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3A8
      Related
      FBpp0076352
      Conserved Domains (1) summary
      cd06902
      Location:33 → 258
      lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain

    2. NM_080037.3 → NP_524776.1  ergic53, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3A8
      Related
      FBpp0290843
      Conserved Domains (1) summary
      cd06902
      Location:33 → 258
      lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3A8 Q9V3A8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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