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    tnc tenectin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tncprovided by FlyBase
    Official Full Name
    tenectinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039257
    Locus tag
    Dmel_CG13648
    See related
    AllianceGenome:FB:FBgn0039257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13648; Dmel\CG13648; Mur96B; Tnc
    Summary
    Predicted to be an extracellular matrix structural constituent. Involved in imaginal disc morphogenesis; regulation of tube diameter; and tube morphogenesis. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including embryonic/larval anal pad; embryonic/larval dorsal vessel; epithelial tube; gut section; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tnc in Genome Data Viewer
    Location:
    96B13-96B15; 3-86 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24984384..25022867)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20810106..20848589)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nicotinamide mononucleotide adenylyltransferase Neighboring gene mahogany Neighboring gene beta-4-galactosyltransferase 7 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene Hormone receptor-like in 96

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tenectin, a novel extracellular matrix protein expressed during Drosophila melanogaster embryonic development. Fraichard S, et al. Gene Expr Patterns, 2006 Oct. PMID 16510317
    2. Hormone-dependent control of developmental timing through regulation of chromatin accessibility. Uyehara CM, et al. Genes Dev, 2017 May 1. PMID 28536147, Free PMC Article
    3. Right time, right place: the temporal regulation of developmental gene expression. Praggastis SA, et al. Genes Dev, 2017 May 1. PMID 28566535, Free PMC Article
    4. A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube. Syed ZA, et al. PLoS Genet, 2012. PMID 22876194, Free PMC Article
    5. Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. Fraichard S, et al. Dev Biol, 2010 Apr 15. PMID 20152825, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tenectin (Tnc) selectively recruits alphaPS2 integrin (alphaPS2/betaPS) integrin at synaptic terminals, but only the cis Tnc/integrin complexes appear to be biologically active.
      Title: Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction.
    2. The regulated expression of Tenectin (Tnc) is critical to shape the Drosophila melanogaster hindgut tube.
      Title: A luminal glycoprotein drives dose-dependent diameter expansion of the Drosophila melanogaster hindgut tube.
    3. Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.
      Title: Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.
    4. Tnc is an extracellular matrix protein secreted in a polarized way in different organs of Drosophila embryos.
      Title: Tenectin, a novel extracellular matrix protein expressed during Drosophila melanogaster embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube diameter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tenectin
    Names
    CG13648-PC
    CG13648-PD
    mucin related 96B
    tnc-PC
    tnc-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24984384..25022867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260371.1 → NP_001247300.1  tenectin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247300.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0UGE6, Q9VC00
      Conserved Domains (5) summary
      pfam09528
      Location:529 → 1065
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      PHA02664
      Location:433 → 595
      PHA02664; hypothetical protein; Provisional
      smart00214
      Location:235 → 296
      VWC; von Willebrand factor (vWF) type C domain
      pfam05904
      Location:1684 → 1788
      DUF863; Plant protein of unknown function (DUF863)
      cl17735
      Location:2762 → 2805
      VWC; von Willebrand factor type C domain

    2. NM_143061.3 → NP_651318.3  tenectin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651318.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0UGE6, Q9VC00
      Conserved Domains (5) summary
      pfam09528
      Location:529 → 1065
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      PHA02664
      Location:433 → 595
      PHA02664; hypothetical protein; Provisional
      smart00214
      Location:235 → 296
      VWC; von Willebrand factor (vWF) type C domain
      pfam05904
      Location:1684 → 1788
      DUF863; Plant protein of unknown function (DUF863)
      cl17735
      Location:2762 → 2805
      VWC; von Willebrand factor type C domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0UGE6 D0UGE6

    Gene LinkOut

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