Mlc2 Myosin light chain 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mlc2provided by FlyBase
Official Full Name: Myosin light chain 2provided by FlyBase
Primary source: FLYBASE:FBgn0002773
Locus tag: Dmel_CG2184
See related: AllianceGenome:FB:FBgn0002773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2184; Dmel\CG2184; Dmlc; dMLC-2; Dmlc2; DmMLC2; dro MLC-2; Ifm(3)99Eb; l(3)99Eb; LC2; MLC; MLC 2; mlc-2; MLC-2; mlc2; MLC2; MRLC; MYL2; myosin; Myosin; p-MLC; RLC; RLC1; RLC2
Summary: Predicted to enable myosin heavy chain binding activity. Involved in flight; muscle system process; and myofibril assembly. Located in myofibril. Is expressed in several structures, including adult head; adult heart; border follicle cell; larval muscle cell; and larval muscle system. Used to study hypertrophic cardiomyopathy 10. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 10. Orthologous to several human genes including MYL10 (myosin light chain 10); MYL11 (myosin light chain 11); and MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99E1-99E1; 3-100 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30171438..30174551, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25997160..26000273, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Mechanism for Activation of Myosin Regulatory Light Chain by Protein Kinase C-Delta in Drosophila.
Title: A Novel Mechanism for Activation of Myosin Regulatory Light Chain by Protein Kinase C-Delta in Drosophila.
The results indicate that the dPix-Git complex controls egg chamber morphogenesis by controlling myosin contractility and Pak kinase downstream of focal adhesions.
Title: The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development.
mutations in DMLC2 manifest differently in song and flight
Title: Mutations of the Drosophila myosin regulatory light chain affect courtship song and reduce reproductive success.
The functional and structural role of the regulatory light chain in chemically skinned fibers at various thick and thin filament lattice spacings.
Title: Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing.
Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila.
Title: Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila.
cycles of myosin-mediated contraction and relaxation, tightly linked to Cdc2 and Rho kinase activity, are directly responsible for the axial expansion of the syncytial nuclei.
Title: Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in flight	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	IMP Inferred from Mutant Phenotype more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myosin light chain 2

Names: CG2184-PA; Mlc2-PA; muscle-specific myosin regulatory light chain; myosin II; myosin II regulatory light chain; myosin LC2; myosin alkali light chain 2; myosin light Chain-2; myosin light chain; myosin light-chain 2; myosin regulatory light chain