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    ppk22 pickpocket 22 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk22provided by FlyBase
    Official Full Name
    pickpocket 22provided by FlyBase
    Primary source
    FLYBASE:FBgn0051105
    Locus tag
    Dmel_CG31105
    See related
    AllianceGenome:FB:FBgn0051105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31105; Dmel\CG31105; FBgn0051105; Ppk22
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta) and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk22 in Genome Data Viewer
    Location:
    96B1-96B1; 3-86 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24857585..24859801, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20683307..20685523, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nicastrin Neighboring gene Histone deacetylase 11 Neighboring gene Carbonic anhydrase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Competition within Introns: Splicing Wins over Polyadenylation via a General Mechanism. Tikhonov M, et al. Acta Naturae, 2013 Oct. PMID 24455183, Free PMC Article
    2. Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Ben-Shahar Y. Adv Genet, 2011. PMID 22099690, Free PMC Article
    3. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article
    4. The genetic architecture of degenerin/epithelial sodium channels in Drosophila. Zelle KM, et al. G3 (Bethesda), 2013 Mar. PMID 23449991, Free PMC Article
    5. Identification of potential mechanosensitive ion channels involved in texture discrimination during Drosophila suzukii egg-laying behaviour. Guo L, et al. Insect Mol Biol, 2020 Oct. PMID 32596943

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 22
    Names
    CG31105-PB
    CG31105-PC
    ppk22-PB
    ppk22-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24857585..24859801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170175.4 → NP_733051.2  pickpocket 22, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733051.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMV2
      Conserved Domains (1) summary
      pfam00858
      Location:46 → 527
      ASC; Amiloride-sensitive sodium channel

    2. NM_001260369.2 → NP_001247298.1  pickpocket 22, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247298.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6G4, Q29QT7
      Conserved Domains (1) summary
      pfam00858
      Location:37 → 135
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6G4 A0A0B4K6G4
    Q8IMV2 Q8IMV2

    Gene LinkOut

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