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    mtg mind the gap [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtgprovided by FlyBase
    Official Full Name
    mind the gapprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260386
    Locus tag
    Dmel_CG7549
    See related
    AllianceGenome:FB:FBgn0260386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0849/10; CG7549; Dmel\CG7549; l(3)S084910; l(3)S084910b; Mtg; MTG
    Summary
    Enables carbohydrate derivative binding activity. Involved in synapse assembly. Located in extracellular space; synaptic cleft; and terminal bouton. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtg in Genome Data Viewer
    Location:
    84F6-84F6; 3-48 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8250497..8260718)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4076219..4086440)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Replication protein A1 Neighboring gene Minichromosome maintenance 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Rushton E, et al. Dev Neurobiol, 2012 Aug. PMID 22234957, Free PMC Article
    2. The role of protein N-glycosylation in neural transmission. Scott H, et al. Glycobiology, 2014 May. PMID 24643084, Free PMC Article
    3. Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments. Rushton E, et al. Dev Dyn, 2009 Mar. PMID 19235718, Free PMC Article
    4. Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction. Wang Q, et al. Elife, 2018 Jun 14. PMID 29901439, Free PMC Article
    5. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens.
      Title: Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens.
    2. Mind-the-gap lectin plays a role in the regulation of neuromuscular junction embryonic synaptogenesis.
      Title: Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate derivative binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic cleft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mind the gap
    Names
    CG7549-PE
    CG7549-PF
    CG7549-PG
    CG7549-PH
    Mind-the-Gap
    lethal (3) S084910b
    mtg-PE
    mtg-PF
    mtg-PG
    mtg-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8250497..8260718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141518.4 → NP_649775.2  mind the gap, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649775.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHA4
      Conserved Domains (1) summary
      pfam01607
      Location:368 → 418
      CBM_14; Chitin binding Peritrophin-A domain

    2. NM_001043221.4 → NP_001036686.3  mind the gap, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036686.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0L7, F3YDJ7, Q0KIA5
      Conserved Domains (1) summary
      pfam01607
      Location:240 → 290
      CBM_14; Chitin binding Peritrophin-A domain

    3. NM_001300302.1 → NP_001287231.1  mind the gap, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5X0L7, F3YDJ7, Q0KIA5
      Conserved Domains (1) summary
      pfam01607
      Location:240 → 290
      CBM_14; Chitin binding Peritrophin-A domain

    4. NM_169212.3 → NP_731221.2  mind the gap, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731221.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHF5
      Conserved Domains (1) summary
      pfam01607
      Location:409 → 459
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHA4 A0A0C4DHA4
    A0A0C4DHF5 A0A0C4DHF5
    Q0KIA5 Q0KIA5
    Q95U23 Q95U23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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