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    SmB Small ribonucleoprotein particle protein SmB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34426, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmBprovided by FlyBase
    Official Full Name
    Small ribonucleoprotein particle protein SmBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262601
    Locus tag
    Dmel_CG5352
    See related
    AllianceGenome:FB:FBgn0262601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B; CG5352; Dmel\CG5352; dSmB; l(2)SH0509; l(2)SH2 0509; Sm B; smb; Smb; SmB1; snRNP B; SYM10
    Summary
    Predicted to enable RNA binding activity and snRNP binding activity. Involved in germ cell development; gonad development; and spermatogenesis. Located in Cajal body and pole plasm. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in Malpighian tubule; adult head; adult heart; oocyte; and pole plasm. Used to study tauopathy. Human ortholog(s) of this gene implicated in Prader-Willi syndrome; cerebrocostomandibular syndrome; and mixed connective tissue disease. Orthologous to several human genes including SNRPB (small nuclear ribonucleoprotein polypeptides B and B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmB in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10425483..10426627, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10425483..10426627, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pineapple eye Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene KDEL receptor Neighboring gene uncharacterized protein Neighboring gene Basal body up regulated gene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of the Drosophila melanogaster, human and murine Sm B cDNAs: evolutionary conservation. Brunet C, et al. Gene, 1993 Feb 28. PMID 7680326
    2. Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors. Raisin-Tani S, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163015
    3. Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. Paterson T, et al. Nucleic Acids Res, 1991 Nov 11. PMID 1834995, Free PMC Article
    4. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. Azzouz TN, et al. RNA, 2003 Dec. PMID 14624008, Free PMC Article
    5. Arginine methylation of SmB is required for Drosophila germ cell development. Anne J. Development, 2010 Sep 1. PMID 20659974

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables snRNP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribonucleoprotein particle protein SmB
    Names
    CG5352-PB
    SmB-PB
    lethal (2) SH0509
    polypeptide B
    small ribonucleoprotein particle protein B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10425483..10426627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201851.2 → NP_001188780.1  small ribonucleoprotein particle protein SmB [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      M9MRL9, Q05856
      Conserved Domains (1) summary
      cd01717
      Location:5 → 82
      Sm_B; Sm protein B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05856.1 Q05856

    Gene LinkOut

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