hh hedgehog [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hhprovided by FlyBase
Official Full Name: hedgehogprovided by FlyBase
Primary source: FLYBASE:FBgn0004644
Locus tag: Dmel_CG4637
See related: AllianceGenome:FB:FBgn0004644
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0134654.19; anon-WO0182946.19; bar; bar-3; bar3; CG4637; Dmel\CG4637; Dmhh; hg; Hg; Hh; HH; l(3)hh; l(3)neo56; l(3)neo57; Mir; Mrt
Summary: Enables morphogen activity and patched binding activity. Involved in several processes, including imaginal disc morphogenesis; open tracheal system development; and regionalization. Located in several cellular components, including cytoplasmic vesicle; extracellular space; and nucleus. Is expressed in several structures, including gut section; imaginal disc; imaginal disc posterior compartment; segment; and somatic precursor cell. Used to study primary bacterial infectious disease. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal (multiple); Hirschsprung's disease; bone development disease (multiple); holoprosencephaly (multiple); and polydactyly (multiple). Orthologous to human IHH (Indian hedgehog signaling molecule); DHH (desert hedgehog signaling molecule); and SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94E1-94E1; 3-78 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23128169..23141906, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18953891..18967628, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad.
Title: Hedgehog signaling guides migration of primordial germ cells to the Drosophila somatic gonad.
Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Title: Phosphatidic acid binding to Patched contributes to the inhibition of Smoothened and Hedgehog signaling in Drosophila wing development.
Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila.
Title: Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila.
The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Title: The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Title: Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.
Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P2 to direct migration of Drosophila embryonic germ cells.
Title: Hedgehog signaling and Tre1 regulate actin dynamics through PI(4,5)P(2) to direct migration of Drosophila embryonic germ cells.
Mechanisms of Smoothened Regulation in Hedgehog Signaling.
Title: Mechanisms of Smoothened Regulation in Hedgehog Signaling.
Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
Title: Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.
Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling.
Title: Regulated delivery controls Drosophila Hedgehog, Wingless, and Decapentaplegic signaling.
Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.
Title: Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc.

Submit: New GeneRIF Correction See all GeneRIFs (181)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables morphogen activity	IDA Inferred from Direct Assay more info	PubMed
enables morphogen activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	IPI Inferred from Physical Interaction more info	PubMed
enables patched binding	NAS Non-traceable Author Statement more info	PubMed
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Bolwig's organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in analia development	TAS Traceable Author Statement more info	PubMed
involved_in anterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in anterior/posterior lineage restriction, imaginal disc	TAS Traceable Author Statement more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling involved in cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compartment pattern specification	TAS Traceable Author Statement more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in cytoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in embryonic pattern specification	IEP Inferred from Expression Pattern more info	PubMed
involved_in epidermis development	TAS Traceable Author Statement more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in foregut morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in genital disc anterior/posterior pattern formation	IEP Inferred from Expression Pattern more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell attraction	TAS Traceable Author Statement more info	PubMed
NOT involved_in germ cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in germ cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonadal mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in heart formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc growth	TAS Traceable Author Statement more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
involved_in labial disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of larval imaginal disc epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucosal immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in posterior head segmentation	TAS Traceable Author Statement more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in progression of morphogenetic furrow involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein autoprocessing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell proliferation involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IEP Inferred from Expression Pattern more info	PubMed
involved_in segment polarity determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in self proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal cell fate specification, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trunk segmentation	TAS Traceable Author Statement more info	PubMed
involved_in ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc anterior/posterior pattern formation	TAS Traceable Author Statement more info	PubMed
involved_in wing disc pattern formation	IDA Inferred from Direct Assay more info	PubMed
involved_in wing disc proximal/distal pattern formation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: hedgehog

Names: CG4637-PB; PKC; atypical; bar-on-3; hedghog; hh-PB; mirabile; moonrat

NP_001034065.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23128169..23141906 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038976.1 → NP_001034065.1 hedgehog [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001034065.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V396, Q02936, Q9VCQ4

Conserved Domains (2) summary

pfam01079
Location:254 → 465

Hint; Hint module

pfam01085
Location:99 → 243

HH_signal; Hedgehog amino-terminal signalling domain