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    Usp20-33 Ubiquitin specific protease 20/33 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36580, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp20-33provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 20/33provided by FlyBase
    Primary source
    FLYBASE:FBgn0033916
    Locus tag
    Dmel_CG8494
    See related
    AllianceGenome:FB:FBgn0033916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8494; Dmel\CG8494; Q7JW61; Usp20; USP20; usp20-33; Usp33
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in nervous system development and regulation of G protein-coupled receptor signaling pathway. Is expressed in adult head and organism. Orthologous to several human genes including USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp20-33 in Genome Data Viewer
    Location:
    50E4-50E5; 2-69 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14239932..14243655)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10127437..10131160)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Optic atrophy 1 Neighboring gene mir-1016 stem loop Neighboring gene SNF related kinase Neighboring gene SET and MYND domain containing, arthropod-specific, member 1 Neighboring gene Multi drug resistance 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Schnall-Levin M, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20729470, Free PMC Article
    2. The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth. Li L, et al. Development, 2013 Dec. PMID 24173801, Free PMC Article
    3. Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. Zhang W, et al. BMC Bioinformatics, 2008 Feb 28. PMID 18307794, Free PMC Article
    4. USP5 Is Dispensable for Monoubiquitin Maintenance in Drosophila. Ristic G, et al. J Biol Chem, 2016 Apr 22. PMID 26917723, Free PMC Article
    5. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 20/33
    Names
    CG8494-PA
    Usp20-33-PA
    NP_610943.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14239932..14243655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137099.3 → NP_610943.2  ubiquitin specific protease 20/33 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610943.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW61, Q8MSP3
      Related
      FBpp0086664
      Conserved Domains (4) summary
      smart00695
      Location:667 → 755
      DUSP; Domain in ubiquitin-specific proteases
      cd02674
      Location:307 → 538
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:80 → 204
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:79 → 538
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JW61 Q7JW61
    Q8MSP3 Q8MSP3
    Q8T0I2 Q8T0I2

    Gene LinkOut

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