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    CG8155 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36698, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8155provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034009
    Locus tag
    Dmel_CG8155
    See related
    AllianceGenome:FB:FBgn0034009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8155
    Summary
    Predicted to enable GTPase activator activity. Involved in determination of adult lifespan. Predicted to be active in autophagosome. Orthologous to human TBC1D25 (TBC1 domain family member 25). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8155 in Genome Data Viewer
    Location:
    51F5-51F6; 2-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15317817..15322171, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11205322..11209676, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transient receptor potential cation channel, subfamily M Neighboring gene NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2 Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum, complementation group C Neighboring gene ADP ribosylation factor 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes. Dyer N, et al. Development, 2007 Dec. PMID 18039970
    2. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
    3. Evi5 promotes collective cell migration through its Rab-GAP activity. Laflamme C, et al. J Cell Biol, 2012 Jul 9. PMID 22778279, Free PMC Article
    4. Misexpression screen delineates novel genes controlling Drosophila lifespan. Paik D, et al. Mech Ageing Dev, 2012 May. PMID 22366109, Free PMC Article
    5. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8155-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15317817..15322171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137185.4 → NP_611029.3  uncharacterized protein Dmel_CG8155 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611029.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BI03
      Conserved Domains (1) summary
      smart00164
      Location:225 → 439
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BI03 Q5BI03
    Q960U5 Q960U5

    Gene LinkOut

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