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    MCTS1 Malignant T cell amplified sequence 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MCTS1provided by FlyBase
    Official Full Name
    Malignant T cell amplified sequence 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029833
    Locus tag
    Dmel_CG5941
    See related
    AllianceGenome:FB:FBgn0029833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.150; anon-WO03040301.151; CG5941; Dmel\CG5941; MCT-1
    Summary
    Predicted to enable RNA binding activity. Involved in translation reinitiation. Part of protein-containing complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to several human genes including MCTS2 (MCTS family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MCTS1 in Genome Data Viewer
    Location:
    5D2-5D2; 1-15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6037892..6039576)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5931925..5933609)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44499 Neighboring gene roughex Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Non-canonical initiation factors modulate repeat-associated non-AUG translation. Green KM, et al. Hum Mol Genet, 2022 Aug 17. PMID 35220421, Free PMC Article
    2. RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames. Zhang T, et al. Nucleic Acids Res, 2024 Jan 25. PMID 38000373, Free PMC Article
    3. DENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth. Schleich S, et al. Nature, 2014 Aug 14. PMID 25043021, Free PMC Article
    4. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article
    5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation reinitiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    malignant T cell amplified sequence 1
    Names
    CG5941-PA
    CG5941-PB
    MCTS1-PA
    MCTS1-PB
    multiple copies in T-cell lymphoma-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6037892..6039576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132060.4 → NP_572288.1  malignant T cell amplified sequence 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W445
      Related
      FBpp0070832
      Conserved Domains (3) summary
      cd11609
      Location:4 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      COG2016
      Location:18 → 177
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
      cl00607
      Location:69 → 173
      PUA; PUA domain

    2. NM_001258612.2 → NP_001245541.1  malignant T cell amplified sequence 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W445
      Conserved Domains (3) summary
      cd11609
      Location:4 → 81
      MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
      COG2016
      Location:18 → 177
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
      cl00607
      Location:69 → 173
      PUA; PUA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W445.1 Q9W445

    Gene LinkOut

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