Glut1 Glucose transporter 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Glut1provided by FlyBase
Official Full Name: Glucose transporter 1provided by FlyBase
Primary source: FLYBASE:FBgn0264574
Locus tag: Dmel_CG43946
See related: AllianceGenome:FB:FBgn0264574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0074/12; CG1086; CG13908; CG43946; Dmel\CG43946; Dmglut1; DmGluT1; DmGLUT1; Glt1; GLU; Glu T1; Glut; GLUT; Glut-1; glut1; GLUT1; l(3)61Ea; l(3)L1H; l(3)S007412
Old locus tag: Dmel_CG1086; Dmel_CG13908
Summary: Predicted to enable hexose transmembrane transporter activity. Involved in glucose homeostasis and positive regulation of peptide hormone secretion. Predicted to be active in membrane. Is expressed in adult head; embryonic antennal sense organ; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose metabolism disease (multiple); glycogen storage disease; myelomeningocele; and obesity. Orthologous to several human genes including SLC2A14 (solute carrier family 2 member 14) and SLC2A3 (solute carrier family 2 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 61D4-61E1; 3-0.5 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (914074..993788)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (914074..993788)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glut1 Functions in Insulin-Producing Neurons to Regulate Lipid and Carbohydrate Storage in Drosophila.
Title: Glut1 Functions in Insulin-Producing Neurons to Regulate Lipid and Carbohydrate Storage in Drosophila.
Glut-1 expression globally depended on histological subtypes and the staining patterns (diffuse or zonal) were different between thymic carcinomas and type B3 thymomas
Title: Glut-1 intensity and pattern of expression in thymic epithelial tumors are predictive of WHO subtypes.
Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness.
Title: Glut-1 glucose transporter expression in esophageal squamous cell carcinoma is associated with tumor aggressiveness.
Glucose transporter 1 transcript levels were higher in the right ventricle than the left ventricle.
Title: Regional heterogeneity in gene expression profiles: a transcript analysis in human and rat heart.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 925231-932599 mobile_element_type = transposon:mdg1{}900

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hexose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monosaccharide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glucose transporter 1

Names: CG43946-PAA; CG43946-PB; CG43946-PC; CG43946-PD; CG43946-PE; CG43946-PJ; CG43946-PL; CG43946-PM; CG43946-PO; CG43946-PP; CG43946-PQ; CG43946-PR; CG43946-PS; CG43946-PT; CG43946-PU; CG43946-PV; CG43946-PW; CG43946-PX; CG43946-PY; CG43946-PZ; Glut1-PAA; Glut1-PB; Glut1-PC; Glut1-PD; Glut1-PE; Glut1-PJ; Glut1-PL; Glut1-PM; Glut1-PO; Glut1-PP; Glut1-PQ; Glut1-PR; Glut1-PS; Glut1-PT; Glut1-PU; Glut1-PV; Glut1-PW; Glut1-PX; Glut1-PY; Glut1-PZ; glucose transporter; lethal (3) S007412

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

914074..993788

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274304.1 → NP_001261233.1 glucose transporter 1, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261233.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:304 → 746

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:305 → 764

Sugar_tr; Sugar (and other) transporter

cl00143
Location:176 → 256

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001274303.1 → NP_001261232.1 glucose transporter 1, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261232.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:121 → 515

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:74 → 533

Sugar_tr; Sugar (and other) transporter

pfam05384
Location:15 → 52

DegS; Sensor protein DegS
NM_001274305.1 → NP_001261234.1 glucose transporter 1, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261234.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6
NM_167846.3 → NP_728558.5 glucose transporter 1, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728558.5

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:253 → 606

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

COG0477
Location:289 → 598

ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

pfam05384
Location:181 → 242

DegS; Sensor protein DegS
NM_001274306.1 → NP_001261235.1 glucose transporter 1, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (1) summary

pfam07851
Location:159 → 251

TMPIT; TMPIT-like protein
NM_001316474.1 → NP_001303403.1 glucose transporter 1, isoform AA [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0S0WFC8

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001299966.1 → NP_001286895.1 glucose transporter 1, isoform Y [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286895.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JG36

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001299967.1 → NP_001286896.1 glucose transporter 1, isoform Z [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286896.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JBV9

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_138229.2 → NP_612073.2 glucose transporter 1, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_612073.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A8JNH6, A8JNH8, A8JNH9, M9PBH4, M9PBH5, M9PDK7, M9PDL1, M9PDS4, M9PDS9, M9PE46, M9PGN5, M9PGP2, O77131, Q0E8K0, Q6NNA9, Q8IRI6, Q95TE8, Q9V409, Q9W0L2

Conserved Domains (2) summary

cd06174
Location:17 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001274309.1 → NP_001261238.1 glucose transporter 1, isoform X [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261238.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (4) summary

cd06174
Location:253 → 688

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR04211
Location:117 → 236

SH3_and_anchor; SH3 domain protein

pfam00083
Location:254 → 706

Sugar_tr; Sugar (and other) transporter

pfam05384
Location:181 → 242

DegS; Sensor protein DegS
NM_001274301.1 → NP_001261230.1 glucose transporter 1, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261230.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001274302.1 → NP_001261231.1 glucose transporter 1, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261231.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JBV9

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001104000.2 → NP_001097470.2 glucose transporter 1, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097470.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (2) summary

cd06174
Location:17 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001274308.1 → NP_001261237.1 glucose transporter 1, isoform W [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261237.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:253 → 688

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:254 → 706

Sugar_tr; Sugar (and other) transporter

pfam05384
Location:181 → 242

DegS; Sensor protein DegS
NM_001103999.4 → NP_001097469.2 glucose transporter 1, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097469.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:152 → 546

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:105 → 564

Sugar_tr; Sugar (and other) transporter

pfam05384
Location:32 → 93

DegS; Sensor protein DegS
NM_001103997.3 → NP_001097467.1 glucose transporter 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097467.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_001274307.1 → NP_001261236.1 glucose transporter 1, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (3) summary

cd06174
Location:253 → 688

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:254 → 706

Sugar_tr; Sugar (and other) transporter

pfam05384
Location:181 → 242

DegS; Sensor protein DegS
NM_001103998.3 → NP_001097468.1 glucose transporter 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097468.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Conserved Domains (2) summary

cd06174
Location:65 → 459

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 477

Sugar_tr; Sugar (and other) transporter
NM_079154.3 → NP_523878.1 glucose transporter 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523878.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Related

FBpp0305681

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter
NM_167845.3 → NP_728557.1 glucose transporter 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728557.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8IRI6

Related

FBpp0305680

Conserved Domains (2) summary

cd06174
Location:65 → 452

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:18 → 470

Sugar_tr; Sugar (and other) transporter