polybromo polybromo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: polybromoprovided by FlyBase
Official Full Name: polybromoprovided by FlyBase
Primary source: FLYBASE:FBgn0039227
Locus tag: Dmel_CG11375
See related: AllianceGenome:FB:FBgn0039227
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.158; baf180; BAF180; bap180; Bap180; CG11375; Dmel\CG11375; Pb; PB; Polybromo; POLYBROMO
Summary: Predicted to enable chromatin binding activity. Involved in cellular component assembly involved in morphogenesis; chromatin remodeling; and negative regulation of transcription by RNA polymerase II. Part of brahma complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; ganglia; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96A22-96A23; 3-85 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24799967..24805259, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20625689..20630981, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that intestinal Bap180 is upregulated by IMD-Relish signalling and then functions as a transcription repressor independent of the PBAP complex to dampen the hyper-inflammatory response in the gut
Title: Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice.
BAP170 and BAP180 act redundantly to allow metamorphosis gene expression profiling of bap170 bap180 double mutants, showed that the PBAP complex regulates genes involved in tissue remodeling and immune system function.
Title: Two subunits specific to the PBAP chromatin remodeling complex have distinct and redundant functions during drosophila development.
Results report the identification of two novel BRM complex-associated proteins: Drosophila Polybromo and BAP170, a conserved protein not described previously
Title: Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in egg chorion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitelline membrane formation involved in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RSC-type complex	IEA Inferred from Electronic Annotation more info
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polybromo

Names: CG11375-PA; polybromo-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24799967..24805259 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143031.2 → NP_651288.1 polybromo [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651288.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU13, Q9VC36

Related

FBpp0084115

Conserved Domains (8) summary

cd05515
Location:641 → 733

Bromo_polybromo_V; Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05517
Location:191 → 294

Bromo_polybromo_II; Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05518
Location:512 → 613

Bromo_polybromo_IV; Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05520
Location:335 → 443

Bromo_polybromo_III; Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd05526
Location:758 → 867

Bromo_polybromo_VI; Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. ...

cd00084
Location:1320 → 1375

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd04717
Location:921 → 1040

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cl02556
Location:46 → 158

Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.