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    tfc triforce [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38141, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tfcprovided by FlyBase
    Official Full Name
    triforceprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035199
    Locus tag
    Dmel_CG9134
    See related
    AllianceGenome:FB:FBgn0035199
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9134; Dmel\CG9134
    Summary
    Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane. Is expressed in embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and larval imaginal tissue. Human ortholog(s) of this gene implicated in several diseases, including dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); lung disease (multiple); respiratory syncytial virus infectious disease; and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule); SFTPA1 (surfactant protein A1); and SFTPA2 (surfactant protein A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See tfc in Genome Data Viewer
    Location:
    61F4-61F4; 3-0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1256449..1274498)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1256449..1274498)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Booster for Crq Neighboring gene uncharacterized protein Neighboring gene Rabaptin-5-associated exchange factor for Rab5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817
    2. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Wei HC, et al. Genome, 2003 Dec. PMID 14663523
    3. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Ostrin EJ, et al. Genome Res, 2006 Apr. PMID 16533912, Free PMC Article
    4. Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Heger A, et al. Genome Res, 2007 Dec. PMID 17989258, Free PMC Article
    5. Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity. Dodd RB, et al. Glycobiology, 2001 May. PMID 11425795

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    triforce
    Names
    CG9134-PA
    CG9134-PB
    CG9134-PC
    tfc-PA
    tfc-PB
    tfc-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1256449..1274498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138247.2 → NP_612091.1  triforce, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRH8
      Related
      FBpp0072553
      Conserved Domains (1) summary
      cd00037
      Location:249 → 373
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. NM_167863.2 → NP_728586.1  triforce, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0I2
      Related
      FBpp0072554
      Conserved Domains (1) summary
      cd00037
      Location:61 → 185
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. NM_167864.2 → NP_728587.1  triforce, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0I2
      Related
      FBpp0072555
      Conserved Domains (1) summary
      cd00037
      Location:61 → 185
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRH8 Q8IRH8
    Q9W0I2 Q9W0I2

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