U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyp6a17 Cytochrome P450 6a17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45556, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cyp6a17provided by FlyBase
    Official Full Name
    Cytochrome P450 6a17provided by FlyBase
    Primary source
    FLYBASE:FBgn0015714
    Locus tag
    Dmel_CG10241
    See related
    AllianceGenome:FB:FBgn0015714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    61D6S; 6a17; CG10241; cyp6a17; Cyp6A17; Dmel\CG10241; ESTS:61D6S; temp
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in thermosensory behavior. Is expressed in several structures, including adult head; adult mushroom body; adult pars intercerebralis; dorsal thoracic disc; and gut section. Human ortholog(s) of this gene implicated in familial Mediterranean fever. Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cyp6a17 in Genome Data Viewer
    Location:
    51D1-51D1; 2-73 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14873953..14875739)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10761458..10763244)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Pcf11 cleavage and polyadenylation factor subunit Neighboring gene Cytochrome P450 6a22 Neighboring gene Cytochrome P450 6a23 Neighboring gene Cytochrome P450 6a19 Neighboring gene Cytochrome P450 6a9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Shah S, et al. Pest Manag Sci, 2012 Jan. PMID 21681918
    2. Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Zhang X, et al. Sci Total Environ, 2023 Aug 25. PMID 37196938
    3. Structural Variants and Selective Sweep Foci Contribute to Insecticide Resistance in the Drosophila Genetic Reference Panel. Battlay P, et al. G3 (Bethesda), 2018 Nov 6. PMID 30190421, Free PMC Article
    4. Novel cytochrome P450, cyp6a17, is required for temperature preference behavior in Drosophila. Kang J, et al. PLoS One, 2011. PMID 22216356, Free PMC Article
    5. Tao Negatively Regulates BMP Signaling During Neuromuscular Junction Development in Drosophila. Politano SF, et al. Dev Neurobiol, 2019 Apr. PMID 31002474, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in thermosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome P450 6a17
    Names
    CG10241-PA
    CG10241-PB
    Cyp6a17-PA
    Cyp6a17-PB
    cytochrome P450
    cytochrome P450-6a17
    NP_001286433.1
    NP_652018.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14873953..14875739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299504.1 → NP_001286433.1  cytochrome P450 6a17, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V770
      UniProtKB/TrEMBL
      A0A0B4LF54
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 478
      p450; Cytochrome P450

    2. NM_143761.4 → NP_652018.1  cytochrome P450 6a17, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652018.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V770
      UniProtKB/TrEMBL
      A0A0B4LF54
      Related
      FBpp0086581
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 478
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF54 A0A0B4LF54
    Q9V770.1 Q9V770

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools