Clc Clathrin light chain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Clcprovided by FlyBase
Official Full Name: Clathrin light chainprovided by FlyBase
Primary source: FLYBASE:FBgn0024814
Locus tag: Dmel_CG6948
See related: AllianceGenome:FB:FBgn0024814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6948; clc; CLC; clc1; Dmel\CG6948
Summary: Predicted to enable clathrin heavy chain binding activity. Involved in clathrin-dependent endocytosis. Located in several cellular components, including cell cortex; clathrin-coated vesicle; and mitotic spindle. Part of clathrin coat of coated pit and clathrin vesicle coat. Is expressed in adult head; adult heart; and embryonic/larval neuromuscular junction. Orthologous to human CLTA (clathrin light chain A) and CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20241053..20243735)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20234153..20236835)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin heavy chain binding	ISS Inferred from Sequence or Structural Similarity more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat of coated pit	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat of coated pit	IEA Inferred from Electronic Annotation more info
part_of clathrin coat of trans-Golgi network vesicle	IEA Inferred from Electronic Annotation more info
part_of clathrin complex	ISS Inferred from Sequence or Structural Similarity more info
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin vesicle coat	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone cytoplasmic component	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6948-PA; CG6948-PB; CG6948-PC; CG6948-PD; Clc-PA; Clc-PB; Clc-PC; Clc-PD; clathrin; clathrin light-chain; clathrin-light-chain

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The following sections contain reference sequences that belong to a specific genome build. Explain