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    mRpS22 mitochondrial ribosomal protein S22 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRpS22provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein S22provided by FlyBase
    Primary source
    FLYBASE:FBgn0039555
    Locus tag
    Dmel_CG12261
    See related
    AllianceGenome:FB:FBgn0039555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56757; CG12261; Dmel\CG12261; MRP-S22; Mrps22; MrpS22; MRPS22
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial small ribosomal subunit. Is expressed in adult head and spermatozoon. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 5 and ovarian dysgenesis 7. Orthologous to human MRPS22 (mitochondrial ribosomal protein S22). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpS22 in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27916908..27918248)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23742630..23743970)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene milkah Neighboring gene BCAS2 Neighboring gene Buddy of Hmr 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Chen A, et al. Hum Mol Genet, 2018 Jun 1. PMID 29566152, Free PMC Article
    2. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Lee LA, et al. Dev Cell, 2005 Mar. PMID 15737938
    3. Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression. Pareek G, et al. PLoS Genet, 2020 Oct. PMID 33075064, Free PMC Article
    4. Energy biogenesis: one key for coordinating two genomes. Sardiello M, et al. Trends Genet, 2005 Jan. PMID 15680507
    5. Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation. Matsushima Y, et al. Sci Rep, 2017 Aug 16. PMID 28814717, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial small ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein S22
    Names
    CG12261-PA
    mRpS22-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27916908..27918248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079813.3 → NP_524537.1  mitochondrial ribosomal protein S22 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524537.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAY9
      Related
      FBpp0084616
      Conserved Domains (1) summary
      pfam10245
      Location:41 → 282
      MRP-S22; Mitochondrial 28S ribosomal protein S22
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAY9 Q9VAY9

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