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    okr okra [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    okrprovided by FlyBase
    Official Full Name
    okraprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002989
    Locus tag
    Dmel_CG3736
    See related
    AllianceGenome:FB:FBgn0002989
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3736; DhR54; Dmel\CG3736; Dmrad54; DmRad54; DmRAD54; Okr; OKR; rad54; Rad54; RAD54; RAD54L; Ras54
    Summary
    Enables ATP hydrolysis activity and ATP-dependent chromatin remodeler activity. Involved in several processes, including DNA metabolic process; oocyte fate determination; and response to ionizing radiation. Located in nucleus. Is expressed in organism and ovary. Human ortholog(s) of this gene implicated in breast cancer; disease of cellular proliferation; non-Hodgkin lymphoma; and pancreatic cancer. Orthologous to human RAD54L (RAD54 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See okr in Genome Data Viewer
    Location:
    23C4-23C4; 2-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2989594..2992759, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2989594..2992759, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromodomain-helicase-DNA-binding protein 1 Neighboring gene Bem46 Neighboring gene uncharacterized protein Neighboring gene Ccdc85

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic integrity and the repair of double-strand DNA breaks. Pastink A, et al. Mutat Res, 2001 Sep 1. PMID 11506797
    2. The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Kooistra R, et al. Mol Cell Biol, 1997 Oct. PMID 9315669, Free PMC Article
    3. The Drosophila melanogaster DNA Ligase IV gene plays a crucial role in the repair of radiation-induced DNA double-strand breaks and acts synergistically with Rad54. Gorski MM, et al. Genetics, 2003 Dec. PMID 14704177, Free PMC Article
    4. The development of a monoclonal antibody recognizing the Drosophila melanogaster phosphorylated histone H2A variant (γ-H2AV). Lake CM, et al. G3 (Bethesda), 2013 Sep 4. PMID 23833215, Free PMC Article
    5. Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila. Romeijn RJ, et al. Genetics, 2005 Feb. PMID 15545651, Free PMC Article

    See all (119) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the frequency of HR dropped significantly in flies homozygous for mutations in spnA (Rad51) or okr (Rad54).
      Title: Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila.
    2. RAD54 is required for repair of DNA double-strand breaks induced by P-element excision.
      Title: Lig4 and rad54 are required for repair of DNA double-strand breaks induced by P-element excision in Drosophila.
    3. A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing. Its autoinhibitory activity is relieved by Rad51.
      Title: A conserved N-terminal motif in Rad54 is important for chromatin remodeling and homologous strand pairing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA synthesis involved in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal appendage formation HMP PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via synthesis-dependent strand annealing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular mRNA localization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in meiotic DNA repair synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in oogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    okra
    Names
    CG3736-PA
    okr-PA
    NP_476661.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2989594..2992759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057313.5 → NP_476661.1  okra [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6UXG7, B6UXH8, B6UXJ2, B6UXJ5, O76460, P91636, Q7K0T1, Q7KPH9
      Related
      FBpp0077357
      Conserved Domains (3) summary
      cd00046
      Location:179 → 328
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:493 → 622
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00176
      Location:159 → 466
      SNF2_N; SNF2 family N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76460.1 O76460

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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