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    Rtca RNA 3'-terminal phosphate cyclase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rtcaprovided by FlyBase
    Official Full Name
    RNA 3'-terminal phosphate cyclaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025630
    Locus tag
    Dmel_CG4061
    See related
    AllianceGenome:FB:FBgn0025630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4061; Dmel\CG4061; EG:22E5.3; RTC1_DROME
    Summary
    Predicted to enable RNA-3'-phosphate cyclase activity. Involved in negative regulation of axon regeneration. Located in nucleus. Is expressed in larval multidendritic class III neuron; larval multidendritic class IV neuron; larval ventral nerve cord; multidendritic neurons; and organism. Orthologous to human RTCA (RNA 3'-terminal phosphate cyclase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rtca in Genome Data Viewer
    Location:
    2C10-2C10; 1-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2072413..2074890)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1966446..1968923)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44382 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 76

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intrinsic mechanisms for axon regeneration: insights from injured axons in Drosophila. Hao Y, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28232273, Free PMC Article
    2. The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration. Vargas EJM, et al. Genes Dev, 2020 Feb 1. PMID 31919191, Free PMC Article
    3. Regulation of axon regeneration by the RNA repair and splicing pathway. Song Y, et al. Nat Neurosci, 2015 Jun. PMID 25961792, Free PMC Article
    4. Models of axon regeneration in Drosophila. Brace EJ, et al. Exp Neurol, 2017 Jan. PMID 26996133, Free PMC Article
    5. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Kind J, et al. Genes Dev, 2007 Aug 15. PMID 17699750, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA-3'-phosphate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-3'-phosphate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA 3'-terminal phosphate cyclase
    Names
    CG4061-PA
    CG4061-PB
    Rtca-PA
    Rtca-PB
    NP_001284801.1
    NP_569977.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2072413..2074890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130621.3 → NP_569977.1  RNA 3'-terminal phosphate cyclase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77264
      UniProtKB/TrEMBL
      X2JI07
      Related
      FBpp0070316
      Conserved Domains (2) summary
      cd00874
      Location:9 → 341
      RNA_Cyclase_Class_II; RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in ...
      TIGR03399
      Location:7 → 338
      RNA_3prim_cycl; RNA 3'-phosphate cyclase

    2. NM_001297872.1 → NP_001284801.1  RNA 3'-terminal phosphate cyclase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284801.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77264
      UniProtKB/TrEMBL
      X2JI07
      Conserved Domains (2) summary
      cd00874
      Location:9 → 341
      RNA_Cyclase_Class_II; RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in ...
      TIGR03399
      Location:7 → 338
      RNA_3prim_cycl; RNA 3'-phosphate cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77264.1 O77264
    X2JI07 X2JI07

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