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    CG17684 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17684provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263780
    Locus tag
    Dmel_CG17684
    See related
    AllianceGenome:FB:FBgn0263780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40072; CG40260; Dmel\CG17684
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; asthma; autosomal dominant intellectual developmental disorder 33; and spinal muscular atrophy. Orthologous to several human genes including DPP10 (dipeptidyl peptidase like 10) and DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17684 in Genome Data Viewer
    Location:
    41A1-41A1; 2-55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (1866080..2262115, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2RHet NW_001848856.1 (609150..1005217, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene antisense RNA:CR46487 Neighboring gene pseudo Neighboring gene Major Facilitator Superfamily Transporter 17 Neighboring gene mir-2279 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Coulthard AB, et al. Genetics, 2010 Jun. PMID 20382826, Free PMC Article
    2. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413
    3. Identifying sleep regulatory genes using a Drosophila model of insomnia. Seugnet L, et al. J Neurosci, 2009 Jun 3. PMID 19494137, Free PMC Article
    4. Comparative transcriptomic analysis of human and Drosophila extracellular vesicles. Lefebvre FA, et al. Sci Rep, 2016 Jun 10. PMID 27282340, Free PMC Article
    5. Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila. Caizzi R, et al. PLoS Genet, 2016 Aug. PMID 27513559, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c1975342-1967694 mobile_element_type = transposon:Stalker2{}6584
    • Loc: c2260657-2259536 mobile_element_type = transposon:1360{}6337

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17684-PC
    CG17684-PD
    NP_001015352.3
    NP_001263157.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      1866080..2262115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015352.4 → NP_001015352.3  uncharacterized protein Dmel_CG17684, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015352.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHM8
      Conserved Domains (2) summary
      pfam00930
      Location:147 → 554
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:643 → 836
      Abhydrolase; alpha/beta hydrolases

    2. NM_001276228.1 → NP_001263157.1  uncharacterized protein Dmel_CG17684, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHN5, A4IJ63
      Conserved Domains (1) summary
      pfam00930
      Location:147 → 437
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0C4DHM8 A0A0C4DHM8
    A0A0C4DHN5 A0A0C4DHN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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