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    Grx5 Glutaredoxin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grx5provided by FlyBase
    Official Full Name
    Glutaredoxin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0030584
    Locus tag
    Dmel_CG14407
    See related
    AllianceGenome:FB:FBgn0030584
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH03087; CG14407; Dmel\CG14407
    Summary
    Predicted to enable disulfide oxidoreductase activity. Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Grx5 in Genome Data Viewer
    Location:
    12F5-12F5; 1-49 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14837471..14838198, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14731504..14732231, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Flotillin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights on thioredoxins (Trxs) and glutaredoxins (Grxs) by in silico amino acid sequence, phylogenetic and comparative structural analyses in organisms of three domains of life. Mondal S, et al. Heliyon, 2022 Oct. PMID 36203893, Free PMC Article
    2. Expansion and evolution of insect GMC oxidoreductases. Iida K, et al. BMC Evol Biol, 2007 May 11. PMID 17498303, Free PMC Article
    3. Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. Hossain MS, et al. J Cell Biol, 2023 Sep 4. PMID 37389657, Free PMC Article
    4. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Mandilaras K, et al. Metallomics, 2012 Aug. PMID 22885802
    5. Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism. Marelja Z, et al. Front Physiol, 2018. PMID 29491838, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-glutathione oxidoreductase (glutathione) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation by iron-sulfur cluster transfer ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutaredoxin 5
    Names
    CG14407-PA
    Grx5-PA
    mitochondrial monothiol glutaredoxin-5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14837471..14838198 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132746.3 → NP_572974.1  glutaredoxin 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXQ5, Q9VY13
      Related
      FBpp0073806
      Conserved Domains (1) summary
      cd03028
      Location:44 → 132
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXQ5 Q8SXQ5

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